On the role of inter-nucleosomal interactions and intrinsic nucleosome dynamics in chromatin function
Evidence is emerging that many diseases result from defects in gene functions, which, in turn, depend on the local chromatin environment of a gene. However, it still remains not fully clear how chromatin activity code is ‘translated’ to the particular ‘activating’ or ‘repressing’ chromatin structura...
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doaj-23bc52376bdd4f2695e97e6924552e1d2020-11-25T00:11:25ZengElsevierBiochemistry and Biophysics Reports2405-58082016-03-015C49250110.1016/j.bbrep.2016.02.009On the role of inter-nucleosomal interactions and intrinsic nucleosome dynamics in chromatin functionWladyslaw A. KrajewskiEvidence is emerging that many diseases result from defects in gene functions, which, in turn, depend on the local chromatin environment of a gene. However, it still remains not fully clear how chromatin activity code is ‘translated’ to the particular ‘activating’ or ‘repressing’ chromatin structural transition. Commonly, chromatin remodeling in vitro was studied using mononucleosomes as a model. However, recent data suggest that structural reorganization of a single mononucleosome is not equal to remodeling of a nucleosome particle under multinucleosomal content – such as, interaction of nucleosomes via flexible histone termini could significantly alter the mode (and the resulting products) of nucleosome structural transitions. It is becoming evident that a nucleosome array does not constitute just a ‘polymer’ of individual ‘canonical’ nucleosomes due to multiple inter-nucleosomal interactions which affect nucleosome dynamics and structure. It could be hypothesized, that inter-nucleosomal interactions could act in cooperation with nucleosome inherent dynamics to orchestrate DNA-based processes and promote formation and stabilization of highly-dynamic, accessible structure of a nucleosome array. In the proposed paper we would like to discuss the nucleosome dynamics within the chromatin fiber mainly as it pertains to the roles of the structural changes mediated by inter-nucleosomal interactions.http://www.sciencedirect.com/science/article/pii/S2405580816300152ChromatinHistonesNucleosomesChromatin remodelingTranscriptionGene activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wladyslaw A. Krajewski |
spellingShingle |
Wladyslaw A. Krajewski On the role of inter-nucleosomal interactions and intrinsic nucleosome dynamics in chromatin function Biochemistry and Biophysics Reports Chromatin Histones Nucleosomes Chromatin remodeling Transcription Gene activity |
author_facet |
Wladyslaw A. Krajewski |
author_sort |
Wladyslaw A. Krajewski |
title |
On the role of inter-nucleosomal interactions and intrinsic nucleosome dynamics in chromatin function |
title_short |
On the role of inter-nucleosomal interactions and intrinsic nucleosome dynamics in chromatin function |
title_full |
On the role of inter-nucleosomal interactions and intrinsic nucleosome dynamics in chromatin function |
title_fullStr |
On the role of inter-nucleosomal interactions and intrinsic nucleosome dynamics in chromatin function |
title_full_unstemmed |
On the role of inter-nucleosomal interactions and intrinsic nucleosome dynamics in chromatin function |
title_sort |
on the role of inter-nucleosomal interactions and intrinsic nucleosome dynamics in chromatin function |
publisher |
Elsevier |
series |
Biochemistry and Biophysics Reports |
issn |
2405-5808 |
publishDate |
2016-03-01 |
description |
Evidence is emerging that many diseases result from defects in gene functions, which, in turn, depend on the local chromatin environment of a gene. However, it still remains not fully clear how chromatin activity code is ‘translated’ to the particular ‘activating’ or ‘repressing’ chromatin structural transition. Commonly, chromatin remodeling in vitro was studied using mononucleosomes as a model. However, recent data suggest that structural reorganization of a single mononucleosome is not equal to remodeling of a nucleosome particle under multinucleosomal content – such as, interaction of nucleosomes via flexible histone termini could significantly alter the mode (and the resulting products) of nucleosome structural transitions. It is becoming evident that a nucleosome array does not constitute just a ‘polymer’ of individual ‘canonical’ nucleosomes due to multiple inter-nucleosomal interactions which affect nucleosome dynamics and structure. It could be hypothesized, that inter-nucleosomal interactions could act in cooperation with nucleosome inherent dynamics to orchestrate DNA-based processes and promote formation and stabilization of highly-dynamic, accessible structure of a nucleosome array. In the proposed paper we would like to discuss the nucleosome dynamics within the chromatin fiber mainly as it pertains to the roles of the structural changes mediated by inter-nucleosomal interactions. |
topic |
Chromatin Histones Nucleosomes Chromatin remodeling Transcription Gene activity |
url |
http://www.sciencedirect.com/science/article/pii/S2405580816300152 |
work_keys_str_mv |
AT wladyslawakrajewski ontheroleofinternucleosomalinteractionsandintrinsicnucleosomedynamicsinchromatinfunction |
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