Mechanisms of Action and Efficacy of Statins against Influenza

Mechanisms of Action and Efficacy of Statins against Influenza

The influenza virus (IV) is known to be a resistant virus with frequent mutations, causing severe respiratory diseases in the upper respiratory system. Public health concerns about clinical efficacy of all conventional drugs are ambiguous; therefore, finding additional therapeutic agents is critical...

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Main Authors: Parvaneh Mehrbod, Abdul Rahman Omar, Mohd Hair-Bejo, Amin Haghani, Aini Ideris
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/872370
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spelling doaj-23c1eeb3063645328d54f582ab09bef22020-11-25T01:06:06ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/872370872370Mechanisms of Action and Efficacy of Statins against InfluenzaParvaneh Mehrbod0Abdul Rahman Omar1Mohd Hair-Bejo2Amin Haghani3Aini Ideris4Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaInstitute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaInstitute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaInstitute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaInstitute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaThe influenza virus (IV) is known to be a resistant virus with frequent mutations, causing severe respiratory diseases in the upper respiratory system. Public health concerns about clinical efficacy of all conventional drugs are ambiguous; therefore, finding additional therapeutic agents is critical to prevent and control influenza outbreaks. Influenza is associated with the induction of proinflammatory cytokines. Scientists have reported that anti-inflammatory drugs, with pleiotropic effects, reduce the burden of severe influenza diseases. Therefore, statins, which are cardioprotective drugs with anti-inflammatory and immunomodulatory effects, may help patients suffering from influenza virus (IV). This review delineates the potential use of statins as an alternative therapy in treating influenza related illness.http://dx.doi.org/10.1155/2014/872370
collection DOAJ
language English
format Article
sources DOAJ
author Parvaneh Mehrbod
Abdul Rahman Omar
Mohd Hair-Bejo
Amin Haghani
Aini Ideris
spellingShingle Parvaneh Mehrbod
Abdul Rahman Omar
Mohd Hair-Bejo
Amin Haghani
Aini Ideris
Mechanisms of Action and Efficacy of Statins against Influenza
BioMed Research International
author_facet Parvaneh Mehrbod
Abdul Rahman Omar
Mohd Hair-Bejo
Amin Haghani
Aini Ideris
author_sort Parvaneh Mehrbod
title Mechanisms of Action and Efficacy of Statins against Influenza
title_short Mechanisms of Action and Efficacy of Statins against Influenza
title_full Mechanisms of Action and Efficacy of Statins against Influenza
title_fullStr Mechanisms of Action and Efficacy of Statins against Influenza
title_full_unstemmed Mechanisms of Action and Efficacy of Statins against Influenza
title_sort mechanisms of action and efficacy of statins against influenza
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2014-01-01
description The influenza virus (IV) is known to be a resistant virus with frequent mutations, causing severe respiratory diseases in the upper respiratory system. Public health concerns about clinical efficacy of all conventional drugs are ambiguous; therefore, finding additional therapeutic agents is critical to prevent and control influenza outbreaks. Influenza is associated with the induction of proinflammatory cytokines. Scientists have reported that anti-inflammatory drugs, with pleiotropic effects, reduce the burden of severe influenza diseases. Therefore, statins, which are cardioprotective drugs with anti-inflammatory and immunomodulatory effects, may help patients suffering from influenza virus (IV). This review delineates the potential use of statins as an alternative therapy in treating influenza related illness.
url http://dx.doi.org/10.1155/2014/872370
work_keys_str_mv AT parvanehmehrbod mechanismsofactionandefficacyofstatinsagainstinfluenza
AT abdulrahmanomar mechanismsofactionandefficacyofstatinsagainstinfluenza
AT mohdhairbejo mechanismsofactionandefficacyofstatinsagainstinfluenza
AT aminhaghani mechanismsofactionandefficacyofstatinsagainstinfluenza
AT ainiideris mechanismsofactionandefficacyofstatinsagainstinfluenza
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