<it>Drosophila </it>as a genetic and cellular model for studies on axonal growth

• Main Authors: Whitington Paul, Tear Guy, Sánchez-Soriano Natalia, Prokop Andreas
• Format: Article
• Language: English
• Published: BMC 2007-05-01
• Series: Neural Development
• Online Access: http://www.neuraldevelopment.com/content/2/1/9

<p>Abstract</p> <p>One of the most fascinating processes during nervous system development is the establishment of stereotypic neuronal networks. An essential step in this process is the outgrowth and precise navigation (pathfinding) of axons and dendrites towards their synaptic partner cells. This phenomenon was first described more than a century ago and, over the past decades, increasing insights have been gained into the cellular and molecular mechanisms regulating neuronal growth and navigation. Progress in this area has been greatly assisted by the use of simple and genetically tractable invertebrate model systems, such as the fruit fly <it>Drosophila melanogaster</it>. This review is dedicated to <it>Drosophila </it>as a genetic and cellular model to study axonal growth and demonstrates how it can and has been used for this research. We describe the various cellular systems of <it>Drosophila </it>used for such studies, insights into axonal growth cones and their cytoskeletal dynamics, and summarise identified molecular signalling pathways required for growth cone navigation, with particular focus on pathfinding decisions in the ventral nerve cord of <it>Drosophila </it>embryos. These <it>Drosophila</it>-specific aspects are viewed in the general context of our current knowledge about neuronal growth.</p>