Meta analysis of infertility due to polycystic ovarian syndrome treated by kidney-tonifying and blood-activating therapy

• Main Authors: Jie-Sha Liang, Yun-Yun Luo
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2020-02-01
• Series: Journal of Hainan Medical University
• Subjects: kidney-tonifying and bloodactivating therapy; infertility; polycystic ovarian syndrome; meta-analysis
• Online Access: http://www.hnykdxxb.com/PDF/202003/12.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To explore the Meta-analysis of polycystic ovary syndrome-induced infertility by tonifying kidney and activating blood circulation. Methods: Chinese keywords or subject words such as "kidney-tonifying and Blood-Activating Therapy", "polycystic ovary syndrome", "infertility" were searched in CNKI, Wanfang and Weipu databases, and English keywords such as "Kidney-tonifying and Blood-Activating Therapy", "Stein-Leventhal syndrome", "Infertility" were searched in Pubmed database for a period of 2. From 2000 to 2019, Metaanalysis was carried out with Review Manager 5.0. Results: Thirteen randomized controlled literatures were screened out, and the control group was treated with routine western medicine and the treatment group was treated with Kidney-tonifying and Blood-activating therapy. All of them included literatures mentioned grouping method, but no blind method was mentioned, and the literature quality was generally low.Meta-analysis of the effective rate showed that Z=3.69(P=0.0002＜0.001), 95%CI(1.77, 6.42), indicating that the effective rate in the treatment group was higher than that in the control group. Meta-analysis of the cycle ovulation rate showed that Z=2.19(P=0.03＜0.05), 95%CI(1.08, 4.35), indicating that the cycle ovulation rate in the treatment group was higher than that in the control group.Metaanalysis of pregnancy rate showed that:Z=7.07(P＜0.00001), 95%CI(2.27, 4.24), indicating that the pregnancy rate in the treatment group was higher than that in the control group; bias analysis found that the literature was distributed on both sides of the dotted line, most of which were biased. Meta-analysis of the incidence of LUFS showed that Z=3.25(P=0.001＜0.05), 95%CI(0.02, 0.38), indicating that the incidence of LUFS in the treatment group was lower than that in the control group. Meta-analysis of serum E2 level after treatment showed that Z=4.41(P＜0.0001), 95%CI(11.01, 28.64), indicating that the serum E2 level in treatment group was higher than that in control group after treatment. Conclusion: Meta-analysis shows that the method of tonifying kidney and activating blood circulation has a significant effect on infertility caused by polycystic ovary syndrome. It can improve the level of sex hormones, improve the efficiency, cycle ovulation rate and pregnancy rate, and reduce the incidence of LUFS. However, the quality of the included literature is not high, which needs to be further included in high-quality literature to confirm.