Siroheme Is Essential for Assimilation of Nitrate and Sulfate as Well as Detoxification of Nitric Oxide but Dispensable for Murine Virulence of Aspergillus fumigatus

Siroheme Is Essential for Assimilation of Nitrate and Sulfate as Well as Detoxification of Nitric Oxide but Dispensable for Murine Virulence of Aspergillus fumigatus

The saprophytic mold Aspergillus fumigatus is the most common airborne fungal pathogen causing severe invasive fungal infections in immunocompromised patients. Siroheme is a heme-like prosthetic group used by plants and microorganisms for sulfate and nitrate assimilation but is absent in higher euka...

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Bibliographic Details
Main Authors: Anna-Maria Dietl, Ulrike Binder, Yana Shadkchan, Nir Osherov, Hubertus Haas
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Microbiology
Subjects:
Aspergillus fumigatus
virulence
siroheme
sulfate and nitrate assimilation
nitric oxide detoxification
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02615/full

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