Detection of acute and chronic toxoplasmosis amongst multi-transfused thalassemia patients in southwest of Iran
Objective: Since pre-transfusion screening for Toxoplasma gondii is not performed on blood packs, thalassemia patients are susceptible to acquiring toxoplasmosis; thus, the aim of this study was to evaluate the seroprevalence status of T. gondii in individuals who suffer from thalassemia in comparis...
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doaj-23fd1e82ea33486c8f4eb95832f1792d2020-11-24T21:39:13ZengWolters Kluwer Medknow PublicationsJournal of Acute Disease2221-61892589-55162017-01-016312012510.12980/jad.6.2017JADWEB-2017-0008Detection of acute and chronic toxoplasmosis amongst multi-transfused thalassemia patients in southwest of IranElham YousefiMasoud ForoutanRoya SalehiShahram KhademvatanObjective: Since pre-transfusion screening for Toxoplasma gondii is not performed on blood packs, thalassemia patients are susceptible to acquiring toxoplasmosis; thus, the aim of this study was to evaluate the seroprevalence status of T. gondii in individuals who suffer from thalassemia in comparison to healthy persons in the southwest of Iran. Methods: In this case-control study, 117 thalassemia patients and 205 healthy persons participated. All samples were tested for the presence of specific IgG and IgM antibodies against T. gondii using ELISA technique. Data were analyzed using Chi-square test. >Results: Seroprevalence of anti-T. gondii IgG was detected in 30.76% (36/117) of patients and 20% (41/205) of healthy individuals (P=0.04), also anti-T. gondii IgM in these groups was detected 1.70% (2/117) and 0.48% (1/205), respectively (P=0.3). In present study, nine related risk factors with toxoplasmosis were evaluated and data analysis showed that only contact with cat was significantly correlated with IgG seroprevalence (P=0.02). >Conclusions: Current research suggests thalassemia patients are more prone than normal persons to acquiring T. gondii infection (P=0.04, OR:1.77). Due to limited studies in this high risk group, further studies are recommended.http://www.jadweb.org/article.asp?issn=2221-6189;year=2017;volume=6;issue=3;spage=120;epage=125;aulast=YousefiToxoplasma gondiiThalassemiaSeroprevalenceIran |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elham Yousefi Masoud Foroutan Roya Salehi Shahram Khademvatan |
spellingShingle |
Elham Yousefi Masoud Foroutan Roya Salehi Shahram Khademvatan Detection of acute and chronic toxoplasmosis amongst multi-transfused thalassemia patients in southwest of Iran Journal of Acute Disease Toxoplasma gondii Thalassemia Seroprevalence Iran |
author_facet |
Elham Yousefi Masoud Foroutan Roya Salehi Shahram Khademvatan |
author_sort |
Elham Yousefi |
title |
Detection of acute and chronic toxoplasmosis amongst multi-transfused thalassemia patients in southwest of Iran |
title_short |
Detection of acute and chronic toxoplasmosis amongst multi-transfused thalassemia patients in southwest of Iran |
title_full |
Detection of acute and chronic toxoplasmosis amongst multi-transfused thalassemia patients in southwest of Iran |
title_fullStr |
Detection of acute and chronic toxoplasmosis amongst multi-transfused thalassemia patients in southwest of Iran |
title_full_unstemmed |
Detection of acute and chronic toxoplasmosis amongst multi-transfused thalassemia patients in southwest of Iran |
title_sort |
detection of acute and chronic toxoplasmosis amongst multi-transfused thalassemia patients in southwest of iran |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Acute Disease |
issn |
2221-6189 2589-5516 |
publishDate |
2017-01-01 |
description |
Objective: Since pre-transfusion screening for Toxoplasma gondii is not performed on blood packs, thalassemia patients are susceptible to acquiring toxoplasmosis; thus, the aim of this study was to evaluate the seroprevalence status of T. gondii in individuals who suffer from thalassemia in comparison to healthy persons in the southwest of Iran.
Methods: In this case-control study, 117 thalassemia patients and 205 healthy persons participated. All samples were tested for the presence of specific IgG and IgM antibodies against T. gondii using ELISA technique. Data were analyzed using Chi-square test.
>Results: Seroprevalence of anti-T. gondii IgG was detected in 30.76% (36/117) of patients and 20% (41/205) of healthy individuals (P=0.04), also anti-T. gondii IgM in these groups was detected 1.70% (2/117) and 0.48% (1/205), respectively (P=0.3). In present study, nine related risk factors with toxoplasmosis were evaluated and data analysis showed that only contact with cat was significantly correlated with IgG seroprevalence (P=0.02).
>Conclusions: Current research suggests thalassemia patients are more prone than normal persons to acquiring T. gondii infection (P=0.04, OR:1.77). Due to limited studies in this high risk group, further studies are recommended. |
topic |
Toxoplasma gondii Thalassemia Seroprevalence Iran |
url |
http://www.jadweb.org/article.asp?issn=2221-6189;year=2017;volume=6;issue=3;spage=120;epage=125;aulast=Yousefi |
work_keys_str_mv |
AT elhamyousefi detectionofacuteandchronictoxoplasmosisamongstmultitransfusedthalassemiapatientsinsouthwestofiran AT masoudforoutan detectionofacuteandchronictoxoplasmosisamongstmultitransfusedthalassemiapatientsinsouthwestofiran AT royasalehi detectionofacuteandchronictoxoplasmosisamongstmultitransfusedthalassemiapatientsinsouthwestofiran AT shahramkhademvatan detectionofacuteandchronictoxoplasmosisamongstmultitransfusedthalassemiapatientsinsouthwestofiran |
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