Why Methodology Is Important: Coffee as a Candidate Treatment for COVID-19?
Background: During this pandemic situation, some studies have led to hasty conclusions about Corona Virus Disease-19 (COVID-19) treatment, due to a lack of methodology. This pedagogic study aimed to highlight potential biases in research on COVID-19 treatment. Methods: We evaluate the effect of coff...
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doaj-23fd609f93644dfeb477ad0cf836f85d2020-11-25T04:10:49ZengMDPI AGJournal of Clinical Medicine2077-03832020-11-0193691369110.3390/jcm9113691Why Methodology Is Important: Coffee as a Candidate Treatment for COVID-19?Yaniss Belaroussi0Paul Roblot1Nathan Peiffer-Smadja2Thomas Delaye3Simone Mathoulin-Pelissier4Joffrey Lemeux5Gwenaël Le Moal6Eric Caumes7France Roblot8Alexandre Bleibtreu9INSERM, Bordeaux Population Health Research Center, ISPED, University of Bordeaux, 33000 Bordeaux, FranceINSERM, Bordeaux Population Health Research Center, ISPED, University of Bordeaux, 33000 Bordeaux, FranceIAME, INSERM, Université de Paris, F-75006 Paris, FranceService de Maladies Infectieuses et Tropicales, CHU Poitiers, 86000 Poitiers, FranceINSERM, Bordeaux Population Health Research Center, ISPED, University of Bordeaux, 33000 Bordeaux, FranceINSERM, Bordeaux Population Health Research Center, ISPED, University of Bordeaux, 33000 Bordeaux, FranceService de Maladies Infectieuses et Tropicales, CHU Poitiers, 86000 Poitiers, FranceAssistance Publique—Hôpitaux de Paris, Hôpitaux Universitaires Pitié-Salpêtrière Charles Foix, Infectious Diseases Department, Pitié-Salpêtrière Hospital, 47–83 Boulevard de l’hôpital, 75013 Paris, FranceService de Maladies Infectieuses et Tropicales, CHU Poitiers, 86000 Poitiers, FranceAssistance Publique—Hôpitaux de Paris, Hôpitaux Universitaires Pitié-Salpêtrière Charles Foix, Infectious Diseases Department, Pitié-Salpêtrière Hospital, 47–83 Boulevard de l’hôpital, 75013 Paris, FranceBackground: During this pandemic situation, some studies have led to hasty conclusions about Corona Virus Disease-19 (COVID-19) treatment, due to a lack of methodology. This pedagogic study aimed to highlight potential biases in research on COVID-19 treatment. Methods: We evaluate the effect of coffee’s active part, 1,3,7-trimethylxanthine (TMX) on patients with COVID-19. A cohort of 93 patients, with a diagnosis of COVID-19 is analyzed. Results: TMX group and control group included, respectively, 26 and 67 patients. In the TMX group, patients had a median length of stay in hospital of 5.5 days shorter than in the control group (9.5 vs. 15 days, <i>p</i> < 0.05). Patients in the control group were more severe than patients in the TMX group with a significantly higher National Early Warning Score 2 (NEWS-2 score) (8 vs. 6, <i>p</i> = 0.002). Conclusions: Multiple biases prevents us from concluding to an effect of coffee on COVID-19. Despite an important social pressure during this crisis, methodology and conscientiousness are the best way to avoid hasty conclusions that can be deleterious for patients. Identifier: NCT04395742.https://www.mdpi.com/2077-0383/9/11/3691coronavirus disease 2019 (COVID-19)current therapiessymptomatic treatmenttrimethylxanthinemethodology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yaniss Belaroussi Paul Roblot Nathan Peiffer-Smadja Thomas Delaye Simone Mathoulin-Pelissier Joffrey Lemeux Gwenaël Le Moal Eric Caumes France Roblot Alexandre Bleibtreu |
spellingShingle |
Yaniss Belaroussi Paul Roblot Nathan Peiffer-Smadja Thomas Delaye Simone Mathoulin-Pelissier Joffrey Lemeux Gwenaël Le Moal Eric Caumes France Roblot Alexandre Bleibtreu Why Methodology Is Important: Coffee as a Candidate Treatment for COVID-19? Journal of Clinical Medicine coronavirus disease 2019 (COVID-19) current therapies symptomatic treatment trimethylxanthine methodology |
author_facet |
Yaniss Belaroussi Paul Roblot Nathan Peiffer-Smadja Thomas Delaye Simone Mathoulin-Pelissier Joffrey Lemeux Gwenaël Le Moal Eric Caumes France Roblot Alexandre Bleibtreu |
author_sort |
Yaniss Belaroussi |
title |
Why Methodology Is Important: Coffee as a Candidate Treatment for COVID-19? |
title_short |
Why Methodology Is Important: Coffee as a Candidate Treatment for COVID-19? |
title_full |
Why Methodology Is Important: Coffee as a Candidate Treatment for COVID-19? |
title_fullStr |
Why Methodology Is Important: Coffee as a Candidate Treatment for COVID-19? |
title_full_unstemmed |
Why Methodology Is Important: Coffee as a Candidate Treatment for COVID-19? |
title_sort |
why methodology is important: coffee as a candidate treatment for covid-19? |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-11-01 |
description |
Background: During this pandemic situation, some studies have led to hasty conclusions about Corona Virus Disease-19 (COVID-19) treatment, due to a lack of methodology. This pedagogic study aimed to highlight potential biases in research on COVID-19 treatment. Methods: We evaluate the effect of coffee’s active part, 1,3,7-trimethylxanthine (TMX) on patients with COVID-19. A cohort of 93 patients, with a diagnosis of COVID-19 is analyzed. Results: TMX group and control group included, respectively, 26 and 67 patients. In the TMX group, patients had a median length of stay in hospital of 5.5 days shorter than in the control group (9.5 vs. 15 days, <i>p</i> < 0.05). Patients in the control group were more severe than patients in the TMX group with a significantly higher National Early Warning Score 2 (NEWS-2 score) (8 vs. 6, <i>p</i> = 0.002). Conclusions: Multiple biases prevents us from concluding to an effect of coffee on COVID-19. Despite an important social pressure during this crisis, methodology and conscientiousness are the best way to avoid hasty conclusions that can be deleterious for patients. Identifier: NCT04395742. |
topic |
coronavirus disease 2019 (COVID-19) current therapies symptomatic treatment trimethylxanthine methodology |
url |
https://www.mdpi.com/2077-0383/9/11/3691 |
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