Comment on “Topically Applied Connective Tissue Growth Factor/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing”
A recent paper in this journal, presented a novel method by topical application of growth factors in stimulating diabetic cutaneous wound healing that caught our attention. We believe that the experimental method in the article is efficient and creative, but it also has some controversies and shortc...
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Series: | Journal of Diabetes Research |
Online Access: | http://dx.doi.org/10.1155/2015/512959 |
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doaj-23fdbf597fe8439a8214b047792dd8712020-11-25T00:46:29ZengHindawi LimitedJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/512959512959Comment on “Topically Applied Connective Tissue Growth Factor/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing”Hongling Li0Cong Cao1Ai Huang2Yi Man3State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, ChinaDepartment of Stomatology, China-Japan Friendship Hospital, No. 2 Yinghuayuan East Road, Beijing 100029, ChinaState Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, ChinaDepartment of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaA recent paper in this journal, presented a novel method by topical application of growth factors in stimulating diabetic cutaneous wound healing that caught our attention. We believe that the experimental method in the article is efficient and creative, but it also has some controversies and shortcomings to be discussed. We noted that the authors used “Tegaderm” as a semiocclusive dressing film and stated that it exerted a “splinting effect” on the wound margins and controlled contraction. Indeed, the “Tegaderm” itself can serve as a dressing film to isolate the wound bed with outside environments while the “splinting effect” is mainly achieved by adding silicone splints around the wound. Considering the unique properties of silicone splints and “Tegaderm,” our experimental group propose an alternative method named “combined-suturing” technique that is not only suturing the silicone splints but also securing the “Tegaderm” around the wound. The specific reasons and operative procedures are explained in detail in this letter.http://dx.doi.org/10.1155/2015/512959 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hongling Li Cong Cao Ai Huang Yi Man |
spellingShingle |
Hongling Li Cong Cao Ai Huang Yi Man Comment on “Topically Applied Connective Tissue Growth Factor/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing” Journal of Diabetes Research |
author_facet |
Hongling Li Cong Cao Ai Huang Yi Man |
author_sort |
Hongling Li |
title |
Comment on “Topically Applied Connective Tissue Growth Factor/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing” |
title_short |
Comment on “Topically Applied Connective Tissue Growth Factor/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing” |
title_full |
Comment on “Topically Applied Connective Tissue Growth Factor/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing” |
title_fullStr |
Comment on “Topically Applied Connective Tissue Growth Factor/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing” |
title_full_unstemmed |
Comment on “Topically Applied Connective Tissue Growth Factor/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing” |
title_sort |
comment on “topically applied connective tissue growth factor/ccn2 improves diabetic preclinical cutaneous wound healing: potential role for ctgf in human diabetic foot ulcer healing” |
publisher |
Hindawi Limited |
series |
Journal of Diabetes Research |
issn |
2314-6745 2314-6753 |
publishDate |
2015-01-01 |
description |
A recent paper in this journal, presented a novel method by topical application of growth factors in stimulating diabetic cutaneous wound healing that caught our attention. We believe that the experimental method in the article is efficient and creative, but it also has some controversies and shortcomings to be discussed. We noted that the authors used “Tegaderm” as a semiocclusive dressing film and stated that it exerted a “splinting effect” on the wound margins and controlled contraction. Indeed, the “Tegaderm” itself can serve as a dressing film to isolate the wound bed with outside environments while the “splinting effect” is mainly achieved by adding silicone splints around the wound. Considering the unique properties of silicone splints and “Tegaderm,” our experimental group propose an alternative method named “combined-suturing” technique that is not only suturing the silicone splints but also securing the “Tegaderm” around the wound. The specific reasons and operative procedures are explained in detail in this letter. |
url |
http://dx.doi.org/10.1155/2015/512959 |
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