CMTM3 suppresses bone formation and osteogenic differentiation of mesenchymal stem cells through inhibiting Erk1/2 and RUNX2 pathways

CMTM3 suppresses bone formation and osteogenic differentiation of mesenchymal stem cells through inhibiting Erk1/2 and RUNX2 pathways

Osteoporosis, fracture, large-scale craniofacial defects and osteonecrosis are hot topics and are still underdiagnosed and undertreated in the clinic. It is urgent to understand the molecular mechanisms corresponding to the regulation of bone formation. CMTM3 (CKLF-like MARVEL transmembrane domain c...

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Bibliographic Details
Main Authors: Dongwei Fan, Daoyang Fan, Wanqiong Yuan
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Genes and Diseases
Subjects:
CMTM3
Erk1/2
hBMSCs
Osteoporosis
RUNX2
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304220301604

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