Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities
Necrotizing Enterocolitis (NEC) is an untreatable intestinal disease in infants. Here the authors show that human and experimental mouse NEC is associated with altered toll-like receptor expression in the intestine, enhanced Th17/type 3 polarization in adaptive immune and innate lymphoid cells, dysr...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19400-w |
| id |
doaj-242592c0bc1c49d49d4bb66a63310f56 |
|---|---|
| record_format |
Article |
| spelling |
doaj-242592c0bc1c49d49d4bb66a63310f562021-05-11T08:19:18ZengNature Publishing GroupNature Communications2041-17232020-11-0111111910.1038/s41467-020-19400-wCharacterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunitiesSteven X. Cho0Ina Rudloff1Jason C. Lao2Merrin A. Pang3Rimma Goldberg4Christine B. Bui5Catriona A. McLean6Magdalena Stock7Tilman E. Klassert8Hortense Slevogt9Niamh E. Mangan10Wei Cheng11Doris Fischer12Stefan Gfroerer13Manjeet K. Sandhu14Devi Ngo15Alexander Bujotzek16Laurent Lariviere17Felix Schumacher18Georg Tiefenthaler19Friederike Beker20Clare Collins21C. Omar F. Kamlin22Kai König23Atul Malhotra24Kenneth Tan25Christiane Theda26Alex Veldman27Andrew M. Ellisdon28James C. Whisstock29Philip J. Berger30Claudia A. Nold-Petry31Marcel F. Nold32Department of Paediatrics, Monash UniversityDepartment of Paediatrics, Monash UniversityDepartment of Paediatrics, Monash UniversityDepartment of Paediatrics, Monash UniversityDepartment of Paediatrics, Monash UniversityDepartment of Paediatrics, Monash UniversityDepartment of Anatomical Pathology, Alfred HospitalZIK Septomics, Jena University HospitalZIK Septomics, Jena University HospitalZIK Septomics, Jena University HospitalDepartment of Molecular and Translational Science, Monash UniversityDepartment of Surgery, Beijing United Family HospitalDepartment of Pediatrics, Goethe University HospitalDepartment of Pediatric Surgery, Goethe University HospitalDepartment of Paediatrics, Monash UniversityDepartment of Paediatrics, Monash UniversityRoche Pharma Research and Early Development, Roche Innovation Center MunichRoche Pharma Research and Early Development, Roche Innovation Center MunichRoche Pharma Research and Early Development, Roche Innovation Center MunichRoche Pharma Research and Early Development, Roche Innovation Center MunichMater Research Institute, University of QueenslandNeonatal Services, Mercy Hospital for WomenDepartment of Newborn Research, Royal Women’s HospitalMedicum Wesemlin, Department of PaediatricsDepartment of Paediatrics, Monash UniversityDepartment of Paediatrics, Monash UniversityDepartment of Newborn Research, Royal Women’s HospitalRitchie Centre, Hudson Institute of Medical ResearchBiomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash UniversityBiomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash UniversityDepartment of Paediatrics, Monash UniversityDepartment of Paediatrics, Monash UniversityDepartment of Paediatrics, Monash UniversityNecrotizing Enterocolitis (NEC) is an untreatable intestinal disease in infants. Here the authors show that human and experimental mouse NEC is associated with altered toll-like receptor expression in the intestine, enhanced Th17/type 3 polarization in adaptive immune and innate lymphoid cells, dysregulated microbiota, and reduced interleukin-37 signaling.https://doi.org/10.1038/s41467-020-19400-w |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Steven X. Cho Ina Rudloff Jason C. Lao Merrin A. Pang Rimma Goldberg Christine B. Bui Catriona A. McLean Magdalena Stock Tilman E. Klassert Hortense Slevogt Niamh E. Mangan Wei Cheng Doris Fischer Stefan Gfroerer Manjeet K. Sandhu Devi Ngo Alexander Bujotzek Laurent Lariviere Felix Schumacher Georg Tiefenthaler Friederike Beker Clare Collins C. Omar F. Kamlin Kai König Atul Malhotra Kenneth Tan Christiane Theda Alex Veldman Andrew M. Ellisdon James C. Whisstock Philip J. Berger Claudia A. Nold-Petry Marcel F. Nold |
| spellingShingle |
Steven X. Cho Ina Rudloff Jason C. Lao Merrin A. Pang Rimma Goldberg Christine B. Bui Catriona A. McLean Magdalena Stock Tilman E. Klassert Hortense Slevogt Niamh E. Mangan Wei Cheng Doris Fischer Stefan Gfroerer Manjeet K. Sandhu Devi Ngo Alexander Bujotzek Laurent Lariviere Felix Schumacher Georg Tiefenthaler Friederike Beker Clare Collins C. Omar F. Kamlin Kai König Atul Malhotra Kenneth Tan Christiane Theda Alex Veldman Andrew M. Ellisdon James C. Whisstock Philip J. Berger Claudia A. Nold-Petry Marcel F. Nold Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities Nature Communications |
| author_facet |
Steven X. Cho Ina Rudloff Jason C. Lao Merrin A. Pang Rimma Goldberg Christine B. Bui Catriona A. McLean Magdalena Stock Tilman E. Klassert Hortense Slevogt Niamh E. Mangan Wei Cheng Doris Fischer Stefan Gfroerer Manjeet K. Sandhu Devi Ngo Alexander Bujotzek Laurent Lariviere Felix Schumacher Georg Tiefenthaler Friederike Beker Clare Collins C. Omar F. Kamlin Kai König Atul Malhotra Kenneth Tan Christiane Theda Alex Veldman Andrew M. Ellisdon James C. Whisstock Philip J. Berger Claudia A. Nold-Petry Marcel F. Nold |
| author_sort |
Steven X. Cho |
| title |
Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities |
| title_short |
Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities |
| title_full |
Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities |
| title_fullStr |
Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities |
| title_full_unstemmed |
Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities |
| title_sort |
characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-11-01 |
| description |
Necrotizing Enterocolitis (NEC) is an untreatable intestinal disease in infants. Here the authors show that human and experimental mouse NEC is associated with altered toll-like receptor expression in the intestine, enhanced Th17/type 3 polarization in adaptive immune and innate lymphoid cells, dysregulated microbiota, and reduced interleukin-37 signaling. |
| url |
https://doi.org/10.1038/s41467-020-19400-w |
| work_keys_str_mv |
AT stevenxcho characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT inarudloff characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT jasonclao characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT merrinapang characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT rimmagoldberg characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT christinebbui characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT catrionaamclean characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT magdalenastock characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT tilmaneklassert characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT hortenseslevogt characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT niamhemangan characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT weicheng characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT dorisfischer characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT stefangfroerer characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT manjeetksandhu characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT devingo characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT alexanderbujotzek characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT laurentlariviere characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT felixschumacher characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT georgtiefenthaler characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT friederikebeker characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT clarecollins characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT comarfkamlin characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT kaikonig characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT atulmalhotra characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT kennethtan characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT christianetheda characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT alexveldman characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT andrewmellisdon characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT jamescwhisstock characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT philipjberger characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT claudiaanoldpetry characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities AT marcelfnold characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities |
| _version_ |
1721450870463266816 |