Potential Role for a Panel of Immunohistochemical Markers in the Management of Endometrial Carcinoma
Background In order to improve the efficacy of endometrial carcinoma (EC) treatment, identifying prognostic factors for high risk patients is a high research priority. This study aimed to assess the relationships among the expression of estrogen receptors (ER), progesterone receptors (PR), human epi...
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doaj-2427c6a383c34e29932199dd6abb6b012020-11-24T21:19:25ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452019-05-0153316417210.4132/jptm.2019.02.1216821Potential Role for a Panel of Immunohistochemical Markers in the Management of Endometrial CarcinomaAmany Salama0Mohammad Arafa1Eman ElZahaf2Abdelhadi Mohamed Shebl3Azmy Abd El-Hameed Awad4Sylvia A. Ashamallah5Reda Hemida6Anas Gamal7Abd AlRahman Foda8Khaled Zalata9El-Said M. Abdel-Hady10 Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University, Mansoura, Egypt Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University, Mansoura, Egypt Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University, Mansoura, EgyptBackground In order to improve the efficacy of endometrial carcinoma (EC) treatment, identifying prognostic factors for high risk patients is a high research priority. This study aimed to assess the relationships among the expression of estrogen receptors (ER), progesterone receptors (PR), human epidermal growth factor receptor 2 (HER2), Ki-67, and the different histopathological prognostic parameters in EC and to assess the value of these in the management of EC. Methods We examined 109 cases of EC. Immunohistochemistry for ER, PR, HER2, and Ki-67 were evaluated in relation to age, tumor size, International Federation of Gynecology and Obstetrics (FIGO) stage and grade, depth of infiltration, cervical and ovarian involvement, lymphovascular space invasion (LVSI), and lymph node (LN) metastasis. Results The mean age of patients in this study was 59.8 ± 8.2 years. Low ER and PR expression scores and high Ki-67 expression showed highly significant associations with non-endometrioid histology (p = .007, p < .001, and p < .001, respectively) and poor differentiation (p = .007, p < .001, and p <. 001, respectively). Low PR score showed a significant association with advanced stage (p = .009). Low ER score was highly associated with LVSI (p = .006), and low PR scores were associated significantly with LN metastasis (p = .026). HER2 expression was significantly related to advanced stages (p = .04), increased depth of infiltration (p = .02), LVSI (p = .017), ovarian involvement (p = .038), and LN metastasis (p = .038). There was a close relationship between HER2 expression and uterine cervical involvement (p = .009). Higher Ki-67 values were associated with LN involvement (p = .012). Conclusions The over-expression of HER2 and Ki-67 and low expression of ER and PR indicate a more malignant EC behavior. An immunohistochemical panel for the identification of high risk tumors can contribute significantly to prognostic assessments.http://www.jpatholtm.org/upload/pdf/jptm-2019-02-12.pdfEndometrial neoplasmsPrognosisSteroid receptorsHER2Ki-67 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amany Salama Mohammad Arafa Eman ElZahaf Abdelhadi Mohamed Shebl Azmy Abd El-Hameed Awad Sylvia A. Ashamallah Reda Hemida Anas Gamal Abd AlRahman Foda Khaled Zalata El-Said M. Abdel-Hady |
spellingShingle |
Amany Salama Mohammad Arafa Eman ElZahaf Abdelhadi Mohamed Shebl Azmy Abd El-Hameed Awad Sylvia A. Ashamallah Reda Hemida Anas Gamal Abd AlRahman Foda Khaled Zalata El-Said M. Abdel-Hady Potential Role for a Panel of Immunohistochemical Markers in the Management of Endometrial Carcinoma Journal of Pathology and Translational Medicine Endometrial neoplasms Prognosis Steroid receptors HER2 Ki-67 |
author_facet |
Amany Salama Mohammad Arafa Eman ElZahaf Abdelhadi Mohamed Shebl Azmy Abd El-Hameed Awad Sylvia A. Ashamallah Reda Hemida Anas Gamal Abd AlRahman Foda Khaled Zalata El-Said M. Abdel-Hady |
author_sort |
Amany Salama |
title |
Potential Role for a Panel of Immunohistochemical Markers in the Management of Endometrial Carcinoma |
title_short |
Potential Role for a Panel of Immunohistochemical Markers in the Management of Endometrial Carcinoma |
title_full |
Potential Role for a Panel of Immunohistochemical Markers in the Management of Endometrial Carcinoma |
title_fullStr |
Potential Role for a Panel of Immunohistochemical Markers in the Management of Endometrial Carcinoma |
title_full_unstemmed |
Potential Role for a Panel of Immunohistochemical Markers in the Management of Endometrial Carcinoma |
title_sort |
potential role for a panel of immunohistochemical markers in the management of endometrial carcinoma |
publisher |
Korean Society of Pathologists & the Korean Society for Cytopathology |
series |
Journal of Pathology and Translational Medicine |
issn |
2383-7837 2383-7845 |
publishDate |
2019-05-01 |
description |
Background In order to improve the efficacy of endometrial carcinoma (EC) treatment, identifying prognostic factors for high risk patients is a high research priority. This study aimed to assess the relationships among the expression of estrogen receptors (ER), progesterone receptors (PR), human epidermal growth factor receptor 2 (HER2), Ki-67, and the different histopathological prognostic parameters in EC and to assess the value of these in the management of EC. Methods We examined 109 cases of EC. Immunohistochemistry for ER, PR, HER2, and Ki-67 were evaluated in relation to age, tumor size, International Federation of Gynecology and Obstetrics (FIGO) stage and grade, depth of infiltration, cervical and ovarian involvement, lymphovascular space invasion (LVSI), and lymph node (LN) metastasis. Results The mean age of patients in this study was 59.8 ± 8.2 years. Low ER and PR expression scores and high Ki-67 expression showed highly significant associations with non-endometrioid histology (p = .007, p < .001, and p < .001, respectively) and poor differentiation (p = .007, p < .001, and p <. 001, respectively). Low PR score showed a significant association with advanced stage (p = .009). Low ER score was highly associated with LVSI (p = .006), and low PR scores were associated significantly with LN metastasis (p = .026). HER2 expression was significantly related to advanced stages (p = .04), increased depth of infiltration (p = .02), LVSI (p = .017), ovarian involvement (p = .038), and LN metastasis (p = .038). There was a close relationship between HER2 expression and uterine cervical involvement (p = .009). Higher Ki-67 values were associated with LN involvement (p = .012). Conclusions The over-expression of HER2 and Ki-67 and low expression of ER and PR indicate a more malignant EC behavior. An immunohistochemical panel for the identification of high risk tumors can contribute significantly to prognostic assessments. |
topic |
Endometrial neoplasms Prognosis Steroid receptors HER2 Ki-67 |
url |
http://www.jpatholtm.org/upload/pdf/jptm-2019-02-12.pdf |
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