Advancements in the Management of HPV-Associated Head and Neck Squamous Cell Carcinoma
Head and neck carcinomas have long been linked to alcohol and tobacco abuse; however, within the last two decades, the human papillomavirus (HPV) has emerged as a third etiology and is specifically associated with head and neck squamous cell carcinomas (HNSCC). In this anatomical region, the oncogen...
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doaj-242892ce0f0c4f79a908ad0b3e68b5ad2020-11-24T22:07:18ZengMDPI AGJournal of Clinical Medicine2077-03832015-04-014582283110.3390/jcm4050822jcm4050822Advancements in the Management of HPV-Associated Head and Neck Squamous Cell CarcinomaRoss Zeitlin0Harrison P. Nguyen1David Rafferty2Stephen Tyring3University of Florida College of Medicine, 1600 SW Archer Rd., Gainesville, FL 32603, USABaylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USAPaul L. Foster School of Medicine, 5001 El Paso Dr., El Paso, TX 79905, USADepartment of Dermatology, University of Texas Medical School at Houston, 6655 Travis Street, Houston, TX 77030, USAHead and neck carcinomas have long been linked to alcohol and tobacco abuse; however, within the last two decades, the human papillomavirus (HPV) has emerged as a third etiology and is specifically associated with head and neck squamous cell carcinomas (HNSCC). In this anatomical region, the oncogenic HPV-16 mediates transformation and immortalization of epithelium, most commonly in the oropharynx. Nevertheless, the recent identification of novel HPV mechanisms thought to be specific to oropharyngeal carcinogenesis has coincided with observations that HPV-associated HNSCC has differing clinical behavior—in terms of natural history, therapeutic response, and prognosis—than HPV-negative head and neck tumors. Taken together with the growing incidence of HPV transmission in younger populations, these discoveries have sparked a rapid expansion in both laboratory and clinical studies on the infection and disease. Herein, we review the clinical characteristics of HPV-associated HNSCC, with particular emphasis on recent advancements in our understanding of the management of this infectious malignancy.http://www.mdpi.com/2077-0383/4/5/822human papillomavirushead and neck squamous cell carcinomaoropharyngeal carcinomaviral carcinogenesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ross Zeitlin Harrison P. Nguyen David Rafferty Stephen Tyring |
spellingShingle |
Ross Zeitlin Harrison P. Nguyen David Rafferty Stephen Tyring Advancements in the Management of HPV-Associated Head and Neck Squamous Cell Carcinoma Journal of Clinical Medicine human papillomavirus head and neck squamous cell carcinoma oropharyngeal carcinoma viral carcinogenesis |
author_facet |
Ross Zeitlin Harrison P. Nguyen David Rafferty Stephen Tyring |
author_sort |
Ross Zeitlin |
title |
Advancements in the Management of HPV-Associated Head and Neck Squamous Cell Carcinoma |
title_short |
Advancements in the Management of HPV-Associated Head and Neck Squamous Cell Carcinoma |
title_full |
Advancements in the Management of HPV-Associated Head and Neck Squamous Cell Carcinoma |
title_fullStr |
Advancements in the Management of HPV-Associated Head and Neck Squamous Cell Carcinoma |
title_full_unstemmed |
Advancements in the Management of HPV-Associated Head and Neck Squamous Cell Carcinoma |
title_sort |
advancements in the management of hpv-associated head and neck squamous cell carcinoma |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2015-04-01 |
description |
Head and neck carcinomas have long been linked to alcohol and tobacco abuse; however, within the last two decades, the human papillomavirus (HPV) has emerged as a third etiology and is specifically associated with head and neck squamous cell carcinomas (HNSCC). In this anatomical region, the oncogenic HPV-16 mediates transformation and immortalization of epithelium, most commonly in the oropharynx. Nevertheless, the recent identification of novel HPV mechanisms thought to be specific to oropharyngeal carcinogenesis has coincided with observations that HPV-associated HNSCC has differing clinical behavior—in terms of natural history, therapeutic response, and prognosis—than HPV-negative head and neck tumors. Taken together with the growing incidence of HPV transmission in younger populations, these discoveries have sparked a rapid expansion in both laboratory and clinical studies on the infection and disease. Herein, we review the clinical characteristics of HPV-associated HNSCC, with particular emphasis on recent advancements in our understanding of the management of this infectious malignancy. |
topic |
human papillomavirus head and neck squamous cell carcinoma oropharyngeal carcinoma viral carcinogenesis |
url |
http://www.mdpi.com/2077-0383/4/5/822 |
work_keys_str_mv |
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