Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ

Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ

We previously reported xanthohumol (XN), and its synthetic derivative tetrahydro-XN (TXN), attenuates high-fat diet (HFD)-induced obesity and metabolic syndrome in C57Bl/6J mice. The objective of the current study was to determine the effect of XN and TXN on lipid accumulation in the liver. Non-supp...

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Bibliographic Details
Main Authors: Yang Zhang, Gerd Bobe, Cristobal L Miranda, Malcolm B Lowry, Victor L Hsu, Christiane V Lohr, Carmen P Wong, Donald B Jump, Matthew M Robinson, Thomas J Sharpton, Claudia S Maier, Jan F Stevens, Adrian F Gombart
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
ppar gamma
xanthohumol
obesity
hepatosteatosis
metabolic syndrome
antagonist
Online Access:https://elifesciences.org/articles/66398

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