The β‐domain of streptokinase affects several functionalities, including specific/proteolytic activity kinetics

The β‐domain of streptokinase affects several functionalities, including specific/proteolytic activity kinetics

Streptokinase (SK) is a plasminogen activator which converts inactive plasminogen (Pg) to active plasmin (Pm), which cleaves fibrin clots. SK secreted by groups A, C, and G Streptococcus (SKA/SKC/SKG) is composed of three domains: SKα, SKβ and SKγ. Previous domain‐swapping studies between SK1/SK2b‐c...

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Bibliographic Details
Main Authors: Maryam Rafipour, Malihe Keramati, Mohammad Mehdi Aslani, Arash Arashkia, Farzin Roohvand
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:FEBS Open Bio
Subjects:
fibrinolysis
plasminogen activation
protein domains
streptococci clusters
streptokinase
α2‐antiplasmin resistance
Online Access:https://doi.org/10.1002/2211-5463.12657

Internet

https://doi.org/10.1002/2211-5463.12657

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