Comparison of beta2-adrenergic and hyperemia-induced arterial vasodilation assessed by digital pulse contour analysis
Introduction. The Reflection Index (RIDVP) derived from digital volume pulse (DVP) analysis has proved to be useful in the assessment of endothelium‑dependent vasodilation induced by albuterol. Little is known of the effect of shear‑stress‑induced vasorelaxation on RIDVP. Material and Methods. Thir...
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doaj-242b91c1d2694e8d97dd575c3842afee2021-08-30T06:55:10ZengPoznan University of Medical SciencesJournal of Medical Science2353-97982353-98012019-03-0188110.20883/jms.330Comparison of beta2-adrenergic and hyperemia-induced arterial vasodilation assessed by digital pulse contour analysisAndrzej Wykretowicz0Karolina Adamska1Przemysław Guzik2Marcin Zwanzig3Mateusz Dziarmaga4Tomasz Krauze5Department of Internal Medicine, Division of Cardiology‑Intensive Therapy, Poznan University of Medical Sciences, PolandDepartment of Internal Medicine, Division of Cardiology‑Intensive Therapy, Poznan University of Medical Sciences, PolandDepartment of Internal Medicine, Division of Cardiology‑Intensive Therapy, Poznan University of Medical Sciences, PolandDepartment of Internal Medicine, Division of Cardiology‑Intensive Therapy, Poznan University of Medical Sciences, PolandDepartment of Internal Medicine, Division of Cardiology‑Intensive Therapy, Poznan University of Medical Sciences, PolandDepartment of Internal Medicine, Division of Cardiology‑Intensive Therapy, Poznan University of Medical Sciences, Poland Introduction. The Reflection Index (RIDVP) derived from digital volume pulse (DVP) analysis has proved to be useful in the assessment of endothelium‑dependent vasodilation induced by albuterol. Little is known of the effect of shear‑stress‑induced vasorelaxation on RIDVP. Material and Methods. Thirty three healthy volunteers (22 females, 11 males, mean age 57 yrs) were recruited. Assessment of endothelium‑dependent vasorelaxation was performed by the analysis of digital volume pulse after albuterol challenge or locally‑induced hyperemia. Results. he hyperemia‑induced vasodilation led to a significant decrease of RIDVP in comparison with the values obtained at rest (∆RIHyper 69 ± 2 % vs 64 ± 2, p < 0.0001). Similarly albuterol administration resulted in a significant drop in RIDVP (∆RIAlb 71 ± 2 % vs 67 ± 2 %, p < 0.0001). There was no significant difference between ∆RIHyper and ∆RIAlb (5.2 ± 0.8 % vs 4.6 ± 1.0 %, p = 0.61). We observed a significant correlation between the small vessel reaction in response to albuterol or hyperemia (r = 0.52, p = 0.01). Conclusions. Our study demonstrated that hyperemia‑induced changes in the Reflexion Index derived from the digital volume pulse are similar to those observed after albuterol‑challenge and both are correlated. https://jms.ump.edu.pl/index.php/JMS/article/view/330endothelial-dependent vasodilationdigital volume pulsealbuterol |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andrzej Wykretowicz Karolina Adamska Przemysław Guzik Marcin Zwanzig Mateusz Dziarmaga Tomasz Krauze |
spellingShingle |
Andrzej Wykretowicz Karolina Adamska Przemysław Guzik Marcin Zwanzig Mateusz Dziarmaga Tomasz Krauze Comparison of beta2-adrenergic and hyperemia-induced arterial vasodilation assessed by digital pulse contour analysis Journal of Medical Science endothelial-dependent vasodilation digital volume pulse albuterol |
author_facet |
Andrzej Wykretowicz Karolina Adamska Przemysław Guzik Marcin Zwanzig Mateusz Dziarmaga Tomasz Krauze |
author_sort |
Andrzej Wykretowicz |
title |
Comparison of beta2-adrenergic and hyperemia-induced arterial vasodilation assessed by digital pulse contour analysis |
title_short |
Comparison of beta2-adrenergic and hyperemia-induced arterial vasodilation assessed by digital pulse contour analysis |
title_full |
Comparison of beta2-adrenergic and hyperemia-induced arterial vasodilation assessed by digital pulse contour analysis |
title_fullStr |
Comparison of beta2-adrenergic and hyperemia-induced arterial vasodilation assessed by digital pulse contour analysis |
title_full_unstemmed |
Comparison of beta2-adrenergic and hyperemia-induced arterial vasodilation assessed by digital pulse contour analysis |
title_sort |
comparison of beta2-adrenergic and hyperemia-induced arterial vasodilation assessed by digital pulse contour analysis |
publisher |
Poznan University of Medical Sciences |
series |
Journal of Medical Science |
issn |
2353-9798 2353-9801 |
publishDate |
2019-03-01 |
description |
Introduction. The Reflection Index (RIDVP) derived from digital volume pulse (DVP) analysis has proved to be useful in the assessment of endothelium‑dependent vasodilation induced by albuterol. Little is known of the effect of shear‑stress‑induced vasorelaxation on RIDVP.
Material and Methods. Thirty three healthy volunteers (22 females, 11 males, mean age 57 yrs) were recruited. Assessment of endothelium‑dependent vasorelaxation was performed by the analysis of digital volume pulse after albuterol challenge or locally‑induced hyperemia.
Results. he hyperemia‑induced vasodilation led to a significant decrease of RIDVP in comparison with the values obtained at rest (∆RIHyper 69 ± 2 % vs 64 ± 2, p < 0.0001). Similarly albuterol administration resulted in a significant drop in RIDVP (∆RIAlb 71 ± 2 % vs 67 ± 2 %, p < 0.0001). There was no significant difference between ∆RIHyper and ∆RIAlb (5.2 ± 0.8 % vs 4.6 ± 1.0 %, p = 0.61). We observed a significant correlation between the small vessel reaction in response to albuterol or hyperemia (r = 0.52, p = 0.01).
Conclusions. Our study demonstrated that hyperemia‑induced changes in the Reflexion Index derived from the digital volume pulse are similar to those observed after albuterol‑challenge and both are correlated.
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topic |
endothelial-dependent vasodilation digital volume pulse albuterol |
url |
https://jms.ump.edu.pl/index.php/JMS/article/view/330 |
work_keys_str_mv |
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