Rapid identification of COVID-19 severity in CT scans through classification of deep features

• Main Authors: Zekuan Yu, Xiaohu Li, Haitao Sun, Jian Wang, Tongtong Zhao, Hongyi Chen, Yichuan Ma, Shujin Zhu, Zongyu Xie
• Format: Article
• Language: English
• Published: BMC 2020-08-01
• Series: BioMedical Engineering OnLine
• Subjects: COVID-19; Tomography; Pneumonia; Coronavirus; Deep learning
• Online Access: http://link.springer.com/article/10.1186/s12938-020-00807-x

Abstract Background Chest CT is used for the assessment of the severity of patients infected with novel coronavirus 2019 (COVID-19). We collected chest CT scans of 202 patients diagnosed with the COVID-19, and try to develop a rapid, accurate and automatic tool for severity screening follow-up therapeutic treatment. Methods A total of 729 2D axial plan slices with 246 severe cases and 483 non-severe cases were employed in this study. By taking the advantages of the pre-trained deep neural network, four pre-trained off-the-shelf deep models (Inception-V3, ResNet-50, ResNet-101, DenseNet-201) were exploited to extract the features from these CT scans. These features are then fed to multiple classifiers (linear discriminant, linear SVM, cubic SVM, KNN and Adaboost decision tree) to identify the severe and non-severe COVID-19 cases. Three validation strategies (holdout validation, tenfold cross-validation and leave-one-out) are employed to validate the feasibility of proposed pipelines. Results and conclusion The experimental results demonstrate that classification of the features from pre-trained deep models shows the promising application in COVID-19 severity screening, whereas the DenseNet-201 with cubic SVM model achieved the best performance. Specifically, it achieved the highest severity classification accuracy of 95.20% and 95.34% for tenfold cross-validation and leave-one-out, respectively. The established pipeline was able to achieve a rapid and accurate identification of the severity of COVID-19. This may assist the physicians to make more efficient and reliable decisions.