Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma
Cancer associated fibroblasts (CAFs) comprise a heterogeneous population that resides within the tumor microenvironment. They actively participate in tumor growth and metastasis by production of cytokines and chemokines, and the release of pro-inflammatory and pro-angiogenic factors, creating a more...
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MDPI AG
2014-06-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/6/3/1363 |
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doaj-24332f35c664445ba9fcd2fc4ea33f1b2020-11-24T22:02:18ZengMDPI AGCancers2072-66942014-06-01631363138110.3390/cancers6031363cancers6031363Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple MyelomaKim De Veirman0Luigia Rao1Elke De Bruyne2Eline Menu3Els Van Valckenborgh4Ivan Van Riet5Maria Antonia Frassanito6Lucia Di Marzo7Angelo Vacca8Karin Vanderkerken9Department of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel (VUB), Brussels 1090, BelgiumDepartment of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel (VUB), Brussels 1090, BelgiumDepartment of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel (VUB), Brussels 1090, BelgiumDepartment of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel (VUB), Brussels 1090, BelgiumDepartment of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel (VUB), Brussels 1090, BelgiumDepartment of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel (VUB), Brussels 1090, BelgiumDepartment of Biomedical Sciences and Human Oncology, Section of General Pathology, University of Bari Medical School, Bari I-70124, ItalyDepartment of Biomedical Sciences and Human Oncology, Section of Internal Medicine, University of Bari Medical School, Bari I-70124, ItalyDepartment of Biomedical Sciences and Human Oncology, Section of Internal Medicine, University of Bari Medical School, Bari I-70124, ItalyDepartment of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel (VUB), Brussels 1090, BelgiumCancer associated fibroblasts (CAFs) comprise a heterogeneous population that resides within the tumor microenvironment. They actively participate in tumor growth and metastasis by production of cytokines and chemokines, and the release of pro-inflammatory and pro-angiogenic factors, creating a more supportive microenvironment. The aim of the current review is to summarize the origin and characteristics of CAFs, and to describe the role of CAFs in tumor progression and metastasis. Furthermore, we focus on the presence of CAFs in hypoxic conditions in relation to multiple myeloma disease.http://www.mdpi.com/2072-6694/6/3/1363multiple myelomahypoxiacancer associated fibroblasts |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kim De Veirman Luigia Rao Elke De Bruyne Eline Menu Els Van Valckenborgh Ivan Van Riet Maria Antonia Frassanito Lucia Di Marzo Angelo Vacca Karin Vanderkerken |
| spellingShingle |
Kim De Veirman Luigia Rao Elke De Bruyne Eline Menu Els Van Valckenborgh Ivan Van Riet Maria Antonia Frassanito Lucia Di Marzo Angelo Vacca Karin Vanderkerken Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma Cancers multiple myeloma hypoxia cancer associated fibroblasts |
| author_facet |
Kim De Veirman Luigia Rao Elke De Bruyne Eline Menu Els Van Valckenborgh Ivan Van Riet Maria Antonia Frassanito Lucia Di Marzo Angelo Vacca Karin Vanderkerken |
| author_sort |
Kim De Veirman |
| title |
Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma |
| title_short |
Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma |
| title_full |
Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma |
| title_fullStr |
Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma |
| title_full_unstemmed |
Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma |
| title_sort |
cancer associated fibroblasts and tumor growth: focus on multiple myeloma |
| publisher |
MDPI AG |
| series |
Cancers |
| issn |
2072-6694 |
| publishDate |
2014-06-01 |
| description |
Cancer associated fibroblasts (CAFs) comprise a heterogeneous population that resides within the tumor microenvironment. They actively participate in tumor growth and metastasis by production of cytokines and chemokines, and the release of pro-inflammatory and pro-angiogenic factors, creating a more supportive microenvironment. The aim of the current review is to summarize the origin and characteristics of CAFs, and to describe the role of CAFs in tumor progression and metastasis. Furthermore, we focus on the presence of CAFs in hypoxic conditions in relation to multiple myeloma disease. |
| topic |
multiple myeloma hypoxia cancer associated fibroblasts |
| url |
http://www.mdpi.com/2072-6694/6/3/1363 |
| work_keys_str_mv |
AT kimdeveirman cancerassociatedfibroblastsandtumorgrowthfocusonmultiplemyeloma AT luigiarao cancerassociatedfibroblastsandtumorgrowthfocusonmultiplemyeloma AT elkedebruyne cancerassociatedfibroblastsandtumorgrowthfocusonmultiplemyeloma AT elinemenu cancerassociatedfibroblastsandtumorgrowthfocusonmultiplemyeloma AT elsvanvalckenborgh cancerassociatedfibroblastsandtumorgrowthfocusonmultiplemyeloma AT ivanvanriet cancerassociatedfibroblastsandtumorgrowthfocusonmultiplemyeloma AT mariaantoniafrassanito cancerassociatedfibroblastsandtumorgrowthfocusonmultiplemyeloma AT luciadimarzo cancerassociatedfibroblastsandtumorgrowthfocusonmultiplemyeloma AT angelovacca cancerassociatedfibroblastsandtumorgrowthfocusonmultiplemyeloma AT karinvanderkerken cancerassociatedfibroblastsandtumorgrowthfocusonmultiplemyeloma |
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