Progress in the Enantioseparation of β-Blockers by Chromatographic Methods

β-adrenergic antagonists (β-blockers) with at least one chiral center are an exceedingly important class of drugs used mostly to treat cardiovascular diseases. At least 70 β-blockers have been investigated in history. However, only a few β-blockers, e.g., timolol, are clinically marketed as an optic...

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Main Authors:	Yiwen Yang, Yehui Wang, Zongbi Bao, Qiwei Yang, Zhiguo Zhang, Qilong Ren
Format:	Article
Language:	English
Published:	MDPI AG 2021-01-01
Series:	Molecules
Subjects:	β-blockers chromatography enantioseparation SFC SMB HPLC
Online Access:	https://www.mdpi.com/1420-3049/26/2/468

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spelling	doaj-243d3253645a4525a3e79fcab02288832021-01-18T00:02:31ZengMDPI AGMolecules1420-30492021-01-012646846810.3390/molecules26020468Progress in the Enantioseparation of β-Blockers by Chromatographic MethodsYiwen Yang0Yehui Wang1Zongbi Bao2Qiwei Yang3Zhiguo Zhang4Qilong Ren5Institute of Pharmaceutical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, ChinaInstitute of Pharmaceutical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, ChinaInstitute of Pharmaceutical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, ChinaInstitute of Pharmaceutical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, ChinaInstitute of Pharmaceutical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, ChinaInstitute of Pharmaceutical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, Chinaβ-adrenergic antagonists (β-blockers) with at least one chiral center are an exceedingly important class of drugs used mostly to treat cardiovascular diseases. At least 70 β-blockers have been investigated in history. However, only a few β-blockers, e.g., timolol, are clinically marketed as an optically pure enantiomer. Therefore, the separation of racemates of β-blockers is essential both in the laboratory and industry. Many approaches have been explored to obtain the single enantiomeric β-blocker, including high performance liquid chromatography, supercritical fluid chromatography and simulated moving bed chromatography. In this article, a review is presented on different chromatographic methods applied for the enantioseparation of β-blockers, covering high performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC) and simulated moving bed chromatography (SMB).https://www.mdpi.com/1420-3049/26/2/468β-blockerschromatographyenantioseparationSFCSMBHPLC
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yiwen Yang Yehui Wang Zongbi Bao Qiwei Yang Zhiguo Zhang Qilong Ren
spellingShingle	Yiwen Yang Yehui Wang Zongbi Bao Qiwei Yang Zhiguo Zhang Qilong Ren Progress in the Enantioseparation of β-Blockers by Chromatographic Methods Molecules β-blockers chromatography enantioseparation SFC SMB HPLC
author_facet	Yiwen Yang Yehui Wang Zongbi Bao Qiwei Yang Zhiguo Zhang Qilong Ren
author_sort	Yiwen Yang
title	Progress in the Enantioseparation of β-Blockers by Chromatographic Methods
title_short	Progress in the Enantioseparation of β-Blockers by Chromatographic Methods
title_full	Progress in the Enantioseparation of β-Blockers by Chromatographic Methods
title_fullStr	Progress in the Enantioseparation of β-Blockers by Chromatographic Methods
title_full_unstemmed	Progress in the Enantioseparation of β-Blockers by Chromatographic Methods
title_sort	progress in the enantioseparation of β-blockers by chromatographic methods
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2021-01-01
description	β-adrenergic antagonists (β-blockers) with at least one chiral center are an exceedingly important class of drugs used mostly to treat cardiovascular diseases. At least 70 β-blockers have been investigated in history. However, only a few β-blockers, e.g., timolol, are clinically marketed as an optically pure enantiomer. Therefore, the separation of racemates of β-blockers is essential both in the laboratory and industry. Many approaches have been explored to obtain the single enantiomeric β-blocker, including high performance liquid chromatography, supercritical fluid chromatography and simulated moving bed chromatography. In this article, a review is presented on different chromatographic methods applied for the enantioseparation of β-blockers, covering high performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC) and simulated moving bed chromatography (SMB).
topic	β-blockers chromatography enantioseparation SFC SMB HPLC
url	https://www.mdpi.com/1420-3049/26/2/468
work_keys_str_mv	AT yiwenyang progressintheenantioseparationofbblockersbychromatographicmethods AT yehuiwang progressintheenantioseparationofbblockersbychromatographicmethods AT zongbibao progressintheenantioseparationofbblockersbychromatographicmethods AT qiweiyang progressintheenantioseparationofbblockersbychromatographicmethods AT zhiguozhang progressintheenantioseparationofbblockersbychromatographicmethods AT qilongren progressintheenantioseparationofbblockersbychromatographicmethods
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Progress in the Enantioseparation of β-Blockers by Chromatographic Methods

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