Erythrocytes as Potential Link between Diabetes and Alzheimer’s Disease
Many studies support the existence of an association between type 2 diabetes (T2DM) and Alzheimer’s disease (AD). In AD, in addition to brain, a number of peripheral tissues and cells are affected, including red blood cell (RBC) and because there are currently no reliable diagnostic biomarkers of AD...
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doaj-243f4c9ae1334a00b85ec4de5d772f542020-11-24T22:02:18ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652017-08-01910.3389/fnagi.2017.00276269007Erythrocytes as Potential Link between Diabetes and Alzheimer’s DiseaseCristiana Carelli-Alinovi0Francesco Misiti1School of Medicine, Biochemistry and Clinical Biochemistry Institute, Università Cattolica del Sacro CuoreRome, ItalyHuman, Social and Health Department, University of Cassino and Lazio MeridionaleCassino, ItalyMany studies support the existence of an association between type 2 diabetes (T2DM) and Alzheimer’s disease (AD). In AD, in addition to brain, a number of peripheral tissues and cells are affected, including red blood cell (RBC) and because there are currently no reliable diagnostic biomarkers of AD in the blood, a gradually increasing attention has been given to the study of RBC’s alterations. Recently it has been evidenced in diabetes, RBC alterations superimposable to the ones occurring in AD RBC. Furthermore, growing evidence suggests that oxidative stress plays a pivotal role in the development of RBC’s alterations and vice versa. Once again this represents a further evidence of a shared pathway between AD and T2DM. The present review summarizes the two disorders, highlighting the role of RBC in the postulated common biochemical links, and suggests RBC as a possible target for clinical trials.http://journal.frontiersin.org/article/10.3389/fnagi.2017.00276/fullAlzheimer’s diseasediabetes mellitus type 2red blood cellsamyloid beta peptideoxidative stressvascular disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cristiana Carelli-Alinovi Francesco Misiti |
spellingShingle |
Cristiana Carelli-Alinovi Francesco Misiti Erythrocytes as Potential Link between Diabetes and Alzheimer’s Disease Frontiers in Aging Neuroscience Alzheimer’s disease diabetes mellitus type 2 red blood cells amyloid beta peptide oxidative stress vascular disease |
author_facet |
Cristiana Carelli-Alinovi Francesco Misiti |
author_sort |
Cristiana Carelli-Alinovi |
title |
Erythrocytes as Potential Link between Diabetes and Alzheimer’s Disease |
title_short |
Erythrocytes as Potential Link between Diabetes and Alzheimer’s Disease |
title_full |
Erythrocytes as Potential Link between Diabetes and Alzheimer’s Disease |
title_fullStr |
Erythrocytes as Potential Link between Diabetes and Alzheimer’s Disease |
title_full_unstemmed |
Erythrocytes as Potential Link between Diabetes and Alzheimer’s Disease |
title_sort |
erythrocytes as potential link between diabetes and alzheimer’s disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2017-08-01 |
description |
Many studies support the existence of an association between type 2 diabetes (T2DM) and Alzheimer’s disease (AD). In AD, in addition to brain, a number of peripheral tissues and cells are affected, including red blood cell (RBC) and because there are currently no reliable diagnostic biomarkers of AD in the blood, a gradually increasing attention has been given to the study of RBC’s alterations. Recently it has been evidenced in diabetes, RBC alterations superimposable to the ones occurring in AD RBC. Furthermore, growing evidence suggests that oxidative stress plays a pivotal role in the development of RBC’s alterations and vice versa. Once again this represents a further evidence of a shared pathway between AD and T2DM. The present review summarizes the two disorders, highlighting the role of RBC in the postulated common biochemical links, and suggests RBC as a possible target for clinical trials. |
topic |
Alzheimer’s disease diabetes mellitus type 2 red blood cells amyloid beta peptide oxidative stress vascular disease |
url |
http://journal.frontiersin.org/article/10.3389/fnagi.2017.00276/full |
work_keys_str_mv |
AT cristianacarellialinovi erythrocytesaspotentiallinkbetweendiabetesandalzheimersdisease AT francescomisiti erythrocytesaspotentiallinkbetweendiabetesandalzheimersdisease |
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1725836486854574080 |