Vaccinations and Infections Are Associated With Unrelated Antibody Titers: An Analysis From the German Birth Cohort Study LISA
The evidence for non-specific effects (NSE) of vaccinations on all-cause morbidity and mortality among children is growing. However, our understanding of the underlying mechanisms is still limited. One hypothesis is that NSE are mediated by antibody titers. We used data of 2,123 children from the po...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-06-01
|
Series: | Frontiers in Pediatrics |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fped.2019.00254/full |
id |
doaj-244f6b184dfd4e97b797ffb9860a5b27 |
---|---|
record_format |
Article |
spelling |
doaj-244f6b184dfd4e97b797ffb9860a5b272020-11-24T21:32:32ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602019-06-01710.3389/fped.2019.00254453625Vaccinations and Infections Are Associated With Unrelated Antibody Titers: An Analysis From the German Birth Cohort Study LISAMahrrouz Caputo0Mahrrouz Caputo1Heike Raupach-Rosin2André Karch3André Karch4André Karch5Michael Borte6Irina Lehmann7Irina Lehmann8Uwe Gerd Liebert9Marie Standl10Joachim Heinrich11Joachim Heinrich12Rafael T. Mikolajczyk13Rafael T. Mikolajczyk14Department of Epidemiology, Helmholtz Centre for Infection Research, Brunswick, GermanyPhD Programme “Epidemiology,” Brunswick, GermanyDepartment of Epidemiology, Helmholtz Centre for Infection Research, Brunswick, GermanyDepartment of Epidemiology, Helmholtz Centre for Infection Research, Brunswick, GermanyGerman Centre for Infection Research (DZIF), Site Brunschwick-Hannover, Brunswick, GermanyInstitute for Epidemiology and Social Medicine, University of Münster, Münster, GermanyChildren's Hospital, Municipal Hospital St. Georg Leipzig, Academic Teaching Hospital of the University of Leipzig, Leipzig, GermanyDepartment of Environmental Immunology, Core Facility Studies, Helmholtz Centre for Environmental Research- UFZ, Leipzig, GermanyCharitè – Universitätsmedizin Berlin and Berlin Institute of Health (BIH), Berlin, GermanyInstitute of Virology, Leipzig University, Leipzig, GermanyHelmholtz Zentrum München- German Research Center for Environmental Health, Institute of Epidemiology, Munich, GermanyHelmholtz Zentrum München- German Research Center for Environmental Health, Institute of Epidemiology, Munich, Germany0Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital of Munich, Ludwig-Maximilians-Universität München, Munich, GermanyGerman Centre for Infection Research (DZIF), Site Brunschwick-Hannover, Brunswick, Germany1Institute for Medical Epidemiology, Biometry, and Informatics (IMEBI), Medical Faculty of the Martin-Luther-University Halle-Wittenberg, Halle (Saale), GermanyThe evidence for non-specific effects (NSE) of vaccinations on all-cause morbidity and mortality among children is growing. However, our understanding of the underlying mechanisms is still limited. One hypothesis is that NSE are mediated by antibody titers. We used data of 2,123 children from the population-based birth cohort study LISA conducted in Germany to explore whether routine childhood vaccinations and the individual infection history in the first 2 years of life are associated with unrelated antibody titers. We selected 19 exposures (infections and vaccinations) and investigated their association with levels of 12 IgG antibody titers at the age of 2 years. Based on univariable analyses (ANOVA), we identified 21 crude associations between exposures and titers (p < 0.05), while 11 (95%-CI: 6, 17) spurious associations were expected due to multiple testing. In exploratory multivariable analyses, we observed associations between seven investigated IgG titers and 10 exposures; either administered vaccines [e.g., higher anti-hRSV IgG titer in BCG-vaccinated children (regression-coefficient in standard-deviation-units: 0.38; 95%-CI: 0.12, 0.65)] or infections [e.g., higher anti-measles IgG titer in children with reported chickenpox (0.44; 95%-CI: 0.08, 0.80)]. Our results indicate the existence of associations between immunogenic exposures and unrelated antibody titers. Further studies investigating the underlying immunological mechanisms are required.https://www.frontiersin.org/article/10.3389/fped.2019.00254/fullhumoral responsevaccinationsinfectious diseasesnon-specific effectsimmune response |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mahrrouz Caputo Mahrrouz Caputo Heike Raupach-Rosin André Karch André Karch André Karch Michael Borte Irina Lehmann Irina Lehmann Uwe Gerd Liebert Marie Standl Joachim Heinrich Joachim Heinrich Rafael T. Mikolajczyk Rafael T. Mikolajczyk |
spellingShingle |
Mahrrouz Caputo Mahrrouz Caputo Heike Raupach-Rosin André Karch André Karch André Karch Michael Borte Irina Lehmann Irina Lehmann Uwe Gerd Liebert Marie Standl Joachim Heinrich Joachim Heinrich Rafael T. Mikolajczyk Rafael T. Mikolajczyk Vaccinations and Infections Are Associated With Unrelated Antibody Titers: An Analysis From the German Birth Cohort Study LISA Frontiers in Pediatrics humoral response vaccinations infectious diseases non-specific effects immune response |
author_facet |
Mahrrouz Caputo Mahrrouz Caputo Heike Raupach-Rosin André Karch André Karch André Karch Michael Borte Irina Lehmann Irina Lehmann Uwe Gerd Liebert Marie Standl Joachim Heinrich Joachim Heinrich Rafael T. Mikolajczyk Rafael T. Mikolajczyk |
author_sort |
Mahrrouz Caputo |
title |
Vaccinations and Infections Are Associated With Unrelated Antibody Titers: An Analysis From the German Birth Cohort Study LISA |
title_short |
Vaccinations and Infections Are Associated With Unrelated Antibody Titers: An Analysis From the German Birth Cohort Study LISA |
title_full |
Vaccinations and Infections Are Associated With Unrelated Antibody Titers: An Analysis From the German Birth Cohort Study LISA |
title_fullStr |
Vaccinations and Infections Are Associated With Unrelated Antibody Titers: An Analysis From the German Birth Cohort Study LISA |
title_full_unstemmed |
Vaccinations and Infections Are Associated With Unrelated Antibody Titers: An Analysis From the German Birth Cohort Study LISA |
title_sort |
vaccinations and infections are associated with unrelated antibody titers: an analysis from the german birth cohort study lisa |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pediatrics |
issn |
2296-2360 |
publishDate |
2019-06-01 |
description |
The evidence for non-specific effects (NSE) of vaccinations on all-cause morbidity and mortality among children is growing. However, our understanding of the underlying mechanisms is still limited. One hypothesis is that NSE are mediated by antibody titers. We used data of 2,123 children from the population-based birth cohort study LISA conducted in Germany to explore whether routine childhood vaccinations and the individual infection history in the first 2 years of life are associated with unrelated antibody titers. We selected 19 exposures (infections and vaccinations) and investigated their association with levels of 12 IgG antibody titers at the age of 2 years. Based on univariable analyses (ANOVA), we identified 21 crude associations between exposures and titers (p < 0.05), while 11 (95%-CI: 6, 17) spurious associations were expected due to multiple testing. In exploratory multivariable analyses, we observed associations between seven investigated IgG titers and 10 exposures; either administered vaccines [e.g., higher anti-hRSV IgG titer in BCG-vaccinated children (regression-coefficient in standard-deviation-units: 0.38; 95%-CI: 0.12, 0.65)] or infections [e.g., higher anti-measles IgG titer in children with reported chickenpox (0.44; 95%-CI: 0.08, 0.80)]. Our results indicate the existence of associations between immunogenic exposures and unrelated antibody titers. Further studies investigating the underlying immunological mechanisms are required. |
topic |
humoral response vaccinations infectious diseases non-specific effects immune response |
url |
https://www.frontiersin.org/article/10.3389/fped.2019.00254/full |
work_keys_str_mv |
AT mahrrouzcaputo vaccinationsandinfectionsareassociatedwithunrelatedantibodytitersananalysisfromthegermanbirthcohortstudylisa AT mahrrouzcaputo vaccinationsandinfectionsareassociatedwithunrelatedantibodytitersananalysisfromthegermanbirthcohortstudylisa AT heikeraupachrosin vaccinationsandinfectionsareassociatedwithunrelatedantibodytitersananalysisfromthegermanbirthcohortstudylisa AT andrekarch vaccinationsandinfectionsareassociatedwithunrelatedantibodytitersananalysisfromthegermanbirthcohortstudylisa AT andrekarch vaccinationsandinfectionsareassociatedwithunrelatedantibodytitersananalysisfromthegermanbirthcohortstudylisa AT andrekarch vaccinationsandinfectionsareassociatedwithunrelatedantibodytitersananalysisfromthegermanbirthcohortstudylisa AT michaelborte vaccinationsandinfectionsareassociatedwithunrelatedantibodytitersananalysisfromthegermanbirthcohortstudylisa AT irinalehmann vaccinationsandinfectionsareassociatedwithunrelatedantibodytitersananalysisfromthegermanbirthcohortstudylisa AT irinalehmann vaccinationsandinfectionsareassociatedwithunrelatedantibodytitersananalysisfromthegermanbirthcohortstudylisa AT uwegerdliebert vaccinationsandinfectionsareassociatedwithunrelatedantibodytitersananalysisfromthegermanbirthcohortstudylisa AT mariestandl vaccinationsandinfectionsareassociatedwithunrelatedantibodytitersananalysisfromthegermanbirthcohortstudylisa AT joachimheinrich vaccinationsandinfectionsareassociatedwithunrelatedantibodytitersananalysisfromthegermanbirthcohortstudylisa AT joachimheinrich vaccinationsandinfectionsareassociatedwithunrelatedantibodytitersananalysisfromthegermanbirthcohortstudylisa AT rafaeltmikolajczyk vaccinationsandinfectionsareassociatedwithunrelatedantibodytitersananalysisfromthegermanbirthcohortstudylisa AT rafaeltmikolajczyk vaccinationsandinfectionsareassociatedwithunrelatedantibodytitersananalysisfromthegermanbirthcohortstudylisa |
_version_ |
1725957074181947392 |