Risk of immune-mediated inflammatory diseases in newly diagnosed ankylosing spondylitis patients: a population-based matched cohort study
Abstract Objective To investigate the risk of immune-mediated inflammatory diseases (IMIDs) in patients with ankylosing spondylitis (AS). Methods Using 2003–2012 claims data from the Taiwanese National Health Insurance Research Database, we identified 30,911 newly diagnosed AS patients requiring med...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2019-08-01
|
Series: | Arthritis Research & Therapy |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13075-019-1980-1 |
id |
doaj-245a9904991a4ecc9aaf9b453a26c9b9 |
---|---|
record_format |
Article |
spelling |
doaj-245a9904991a4ecc9aaf9b453a26c9b92020-11-25T03:41:18ZengBMCArthritis Research & Therapy1478-63622019-08-012111910.1186/s13075-019-1980-1Risk of immune-mediated inflammatory diseases in newly diagnosed ankylosing spondylitis patients: a population-based matched cohort studyHsin-Hua Chen0Wen-Cheng Chao1Yi-Hsing Chen2Tsu-Yi Hsieh3Kuo-Lung Lai4Yi-Ming Chen5Wei-Ting Hung6Ching-Tsai Lin7Chih-Wei Tseng8Ching-Heng Lin9Department of Medical Research, Taichung Veterans General HospitalDepartment of Medical Research, Taichung Veterans General HospitalDivision of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General HospitalDivision of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General HospitalDivision of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General HospitalDepartment of Medical Research, Taichung Veterans General HospitalDivision of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General HospitalDivision of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General HospitalDivision of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General HospitalDepartment of Medical Research, Taichung Veterans General HospitalAbstract Objective To investigate the risk of immune-mediated inflammatory diseases (IMIDs) in patients with ankylosing spondylitis (AS). Methods Using 2003–2012 claims data from the Taiwanese National Health Insurance Research Database, we identified 30,911 newly diagnosed AS patients requiring medical therapy from 2006 to 2012. In addition, we randomly selected 309,110 non-AS individuals matching (1:10) the AS patients with regard to age, sex and the year of the index date. After excluding subjects with the corresponding prior IMIDs, we calculated the incidence rates (IRs) of various IMIDs in the AS and non-AS cohorts and estimated the hazard ratios (HRs) with 95% confidence intervals after adjusting for age, sex, the Charlson comorbidity index, the frequency of ambulatory visits during the follow-up period and medications. We conducted sensitivity analyses by excluding those who developed IMIDs within 3 months after the index date. Results In the follow-up period, we found that newly diagnosed AS patients had significantly increased risks of acute anterior uveitis, psoriasis, Sjögren’s syndrome, thromboangiitis obliterans, Behcet’s disease and sarcoidosis. However, the risk of Sjögren’s syndrome did not increase in AS patients in the sensitivity analysis. In the same period, this study found no significant differences in the risks of Crohn’s disease, ulcerative colitis, systemic lupus erythematosus, systemic sclerosis, dermatomyositis, polymyositis, pemphigus and vitiligo between newly diagnosed AS patients and non-AS individuals. AS patients had a significantly reduced risk of rheumatoid arthritis. Conclusion Newly diagnosed Taiwanese AS patients had increased risks of acute anterior uveitis, psoriasis, thromboangiitis obliterans, Behcet’s disease and sarcoidosis, but a reduced risk of rheumatoid arthritis.http://link.springer.com/article/10.1186/s13075-019-1980-1Ankylosing spondylitisImmune-mediated inflammatory diseaseIncidence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hsin-Hua Chen Wen-Cheng Chao Yi-Hsing Chen Tsu-Yi Hsieh Kuo-Lung Lai Yi-Ming Chen Wei-Ting Hung Ching-Tsai Lin Chih-Wei Tseng Ching-Heng Lin |
spellingShingle |
Hsin-Hua Chen Wen-Cheng Chao Yi-Hsing Chen Tsu-Yi Hsieh Kuo-Lung Lai Yi-Ming Chen Wei-Ting Hung Ching-Tsai Lin Chih-Wei Tseng Ching-Heng Lin Risk of immune-mediated inflammatory diseases in newly diagnosed ankylosing spondylitis patients: a population-based matched cohort study Arthritis Research & Therapy Ankylosing spondylitis Immune-mediated inflammatory disease Incidence |
author_facet |
Hsin-Hua Chen Wen-Cheng Chao Yi-Hsing Chen Tsu-Yi Hsieh Kuo-Lung Lai Yi-Ming Chen Wei-Ting Hung Ching-Tsai Lin Chih-Wei Tseng Ching-Heng Lin |
author_sort |
Hsin-Hua Chen |
title |
Risk of immune-mediated inflammatory diseases in newly diagnosed ankylosing spondylitis patients: a population-based matched cohort study |
title_short |
Risk of immune-mediated inflammatory diseases in newly diagnosed ankylosing spondylitis patients: a population-based matched cohort study |
title_full |
Risk of immune-mediated inflammatory diseases in newly diagnosed ankylosing spondylitis patients: a population-based matched cohort study |
title_fullStr |
Risk of immune-mediated inflammatory diseases in newly diagnosed ankylosing spondylitis patients: a population-based matched cohort study |
title_full_unstemmed |
Risk of immune-mediated inflammatory diseases in newly diagnosed ankylosing spondylitis patients: a population-based matched cohort study |
title_sort |
risk of immune-mediated inflammatory diseases in newly diagnosed ankylosing spondylitis patients: a population-based matched cohort study |
publisher |
BMC |
series |
Arthritis Research & Therapy |
issn |
1478-6362 |
publishDate |
2019-08-01 |
description |
Abstract Objective To investigate the risk of immune-mediated inflammatory diseases (IMIDs) in patients with ankylosing spondylitis (AS). Methods Using 2003–2012 claims data from the Taiwanese National Health Insurance Research Database, we identified 30,911 newly diagnosed AS patients requiring medical therapy from 2006 to 2012. In addition, we randomly selected 309,110 non-AS individuals matching (1:10) the AS patients with regard to age, sex and the year of the index date. After excluding subjects with the corresponding prior IMIDs, we calculated the incidence rates (IRs) of various IMIDs in the AS and non-AS cohorts and estimated the hazard ratios (HRs) with 95% confidence intervals after adjusting for age, sex, the Charlson comorbidity index, the frequency of ambulatory visits during the follow-up period and medications. We conducted sensitivity analyses by excluding those who developed IMIDs within 3 months after the index date. Results In the follow-up period, we found that newly diagnosed AS patients had significantly increased risks of acute anterior uveitis, psoriasis, Sjögren’s syndrome, thromboangiitis obliterans, Behcet’s disease and sarcoidosis. However, the risk of Sjögren’s syndrome did not increase in AS patients in the sensitivity analysis. In the same period, this study found no significant differences in the risks of Crohn’s disease, ulcerative colitis, systemic lupus erythematosus, systemic sclerosis, dermatomyositis, polymyositis, pemphigus and vitiligo between newly diagnosed AS patients and non-AS individuals. AS patients had a significantly reduced risk of rheumatoid arthritis. Conclusion Newly diagnosed Taiwanese AS patients had increased risks of acute anterior uveitis, psoriasis, thromboangiitis obliterans, Behcet’s disease and sarcoidosis, but a reduced risk of rheumatoid arthritis. |
topic |
Ankylosing spondylitis Immune-mediated inflammatory disease Incidence |
url |
http://link.springer.com/article/10.1186/s13075-019-1980-1 |
work_keys_str_mv |
AT hsinhuachen riskofimmunemediatedinflammatorydiseasesinnewlydiagnosedankylosingspondylitispatientsapopulationbasedmatchedcohortstudy AT wenchengchao riskofimmunemediatedinflammatorydiseasesinnewlydiagnosedankylosingspondylitispatientsapopulationbasedmatchedcohortstudy AT yihsingchen riskofimmunemediatedinflammatorydiseasesinnewlydiagnosedankylosingspondylitispatientsapopulationbasedmatchedcohortstudy AT tsuyihsieh riskofimmunemediatedinflammatorydiseasesinnewlydiagnosedankylosingspondylitispatientsapopulationbasedmatchedcohortstudy AT kuolunglai riskofimmunemediatedinflammatorydiseasesinnewlydiagnosedankylosingspondylitispatientsapopulationbasedmatchedcohortstudy AT yimingchen riskofimmunemediatedinflammatorydiseasesinnewlydiagnosedankylosingspondylitispatientsapopulationbasedmatchedcohortstudy AT weitinghung riskofimmunemediatedinflammatorydiseasesinnewlydiagnosedankylosingspondylitispatientsapopulationbasedmatchedcohortstudy AT chingtsailin riskofimmunemediatedinflammatorydiseasesinnewlydiagnosedankylosingspondylitispatientsapopulationbasedmatchedcohortstudy AT chihweitseng riskofimmunemediatedinflammatorydiseasesinnewlydiagnosedankylosingspondylitispatientsapopulationbasedmatchedcohortstudy AT chinghenglin riskofimmunemediatedinflammatorydiseasesinnewlydiagnosedankylosingspondylitispatientsapopulationbasedmatchedcohortstudy |
_version_ |
1724530469322620928 |