Synergistic effects of dopamine and Zn2+ on the induction of PC12 cell death and dopamine depletion in the striatum: possible implication in the pathogenesis of Parkinson's disease
The mechanism that underlies the progressive degeneration of the dopaminergic neurons in Parkinson's disease (PD) is not clear. The Zn2+ level in the substantia nigra of Parkinson's patients is increased. However, it is unknown whether Zn2+ has a role in the degeneration of dopaminergic ne...
Main Authors: | Hsiao-Sui Lo, Hsueh-Cheng Chiang, Anya M.Y. Lin, Han-Yun Chiang, Yeh-Chiu Chu, Lung-Sen Kao |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2004-10-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996104001093 |
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