The Association of On-Admission Blood Hemoglobin, C-Reactive Protein, and Serum Creatinine With 2-Year Mortality of Patients With Femoral Neck Fractures
Introduction The mortality of femoral neck fracture (FNF) is high and every effort should be made to identify and manage any possible risk factors. The aim of this study was to evaluate whether on-admission hemoglobin (Hb) level, C-reactive protein (CRP), and serum creatinine were associated with 2-...
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doaj-246f05a320ff47b8a8363840dda5aea62021-08-18T21:34:40ZengSAGE PublishingGeriatric Orthopaedic Surgery & Rehabilitation2151-45932021-08-011210.1177/21514593211037758The Association of On-Admission Blood Hemoglobin, C-Reactive Protein, and Serum Creatinine With 2-Year Mortality of Patients With Femoral Neck FracturesArkan Sayed-Noor MD, PhDBariq Al-Amiry MD, PhDAlan Alwan MDBjörn Knutsson MD, PhDBjörn Barenius MD, PhDIntroduction The mortality of femoral neck fracture (FNF) is high and every effort should be made to identify and manage any possible risk factors. The aim of this study was to evaluate whether on-admission hemoglobin (Hb) level, C-reactive protein (CRP), and serum creatinine were associated with 2-year mortality after FNF. Patients and Methods In this retrospective observational cohort study, we considered for inclusion all displaced FNF patients 65 years and above treated with hemi-arthroplasty between February 2011 and May 2015. We documented the age, sex, cognitive status, and American Society of Anesthesiologists (ASA) classification. The Hb level, CRP, and serum creatinine were measured. The medical records were followed up for 2 years. We fitted different crude and adjusted Cox proportional hazards models to examine whether Hb level <100 g/L, CRP >20 mg/L, and serum creatinine >100 μmol/L were associated with the 2-year mortality, adjusted for age, sex, and ASA class. Results A total of 290 patients [208 females (72%), mean age 84 years] were included in the study. More than 50% of patients had impaired cognition and ASA class 3–4. Of the 290 patients, 38.3% ( n = 111) had died within 2 years after surgery. Mortality among males was 46.3% ( n = 38) while mortality among females was 35,1% ( n = 73), p = 0.07. We found that on-admission Hb level <100 g/L was associated with 2-year mortality (HR = 3.3, 95% CI: 1.3–8.3, p < 0.01) while CRP >20 mg/L and serum creatinine >100 μmol/L were not associated with 2-year mortality ( p = 0.89 and p = 0.31, respectively). Conclusion On-admission Hb level <100 g/L, but not CRP >20 mg/L and serum creatinine >100 μmol/L, was associated with 2-year mortality. These results can help healthcare providers identify high-risk FNF patients who probably would benefit from optimized perioperative medical management.https://doi.org/10.1177/21514593211037758 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Arkan Sayed-Noor MD, PhD Bariq Al-Amiry MD, PhD Alan Alwan MD Björn Knutsson MD, PhD Björn Barenius MD, PhD |
spellingShingle |
Arkan Sayed-Noor MD, PhD Bariq Al-Amiry MD, PhD Alan Alwan MD Björn Knutsson MD, PhD Björn Barenius MD, PhD The Association of On-Admission Blood Hemoglobin, C-Reactive Protein, and Serum Creatinine With 2-Year Mortality of Patients With Femoral Neck Fractures Geriatric Orthopaedic Surgery & Rehabilitation |
author_facet |
Arkan Sayed-Noor MD, PhD Bariq Al-Amiry MD, PhD Alan Alwan MD Björn Knutsson MD, PhD Björn Barenius MD, PhD |
author_sort |
Arkan Sayed-Noor MD, PhD |
title |
The Association of On-Admission Blood Hemoglobin, C-Reactive Protein, and Serum Creatinine With 2-Year Mortality of Patients With Femoral Neck Fractures |
title_short |
The Association of On-Admission Blood Hemoglobin, C-Reactive Protein, and Serum Creatinine With 2-Year Mortality of Patients With Femoral Neck Fractures |
title_full |
The Association of On-Admission Blood Hemoglobin, C-Reactive Protein, and Serum Creatinine With 2-Year Mortality of Patients With Femoral Neck Fractures |
title_fullStr |
The Association of On-Admission Blood Hemoglobin, C-Reactive Protein, and Serum Creatinine With 2-Year Mortality of Patients With Femoral Neck Fractures |
title_full_unstemmed |
The Association of On-Admission Blood Hemoglobin, C-Reactive Protein, and Serum Creatinine With 2-Year Mortality of Patients With Femoral Neck Fractures |
title_sort |
association of on-admission blood hemoglobin, c-reactive protein, and serum creatinine with 2-year mortality of patients with femoral neck fractures |
publisher |
SAGE Publishing |
series |
Geriatric Orthopaedic Surgery & Rehabilitation |
issn |
2151-4593 |
publishDate |
2021-08-01 |
description |
Introduction The mortality of femoral neck fracture (FNF) is high and every effort should be made to identify and manage any possible risk factors. The aim of this study was to evaluate whether on-admission hemoglobin (Hb) level, C-reactive protein (CRP), and serum creatinine were associated with 2-year mortality after FNF. Patients and Methods In this retrospective observational cohort study, we considered for inclusion all displaced FNF patients 65 years and above treated with hemi-arthroplasty between February 2011 and May 2015. We documented the age, sex, cognitive status, and American Society of Anesthesiologists (ASA) classification. The Hb level, CRP, and serum creatinine were measured. The medical records were followed up for 2 years. We fitted different crude and adjusted Cox proportional hazards models to examine whether Hb level <100 g/L, CRP >20 mg/L, and serum creatinine >100 μmol/L were associated with the 2-year mortality, adjusted for age, sex, and ASA class. Results A total of 290 patients [208 females (72%), mean age 84 years] were included in the study. More than 50% of patients had impaired cognition and ASA class 3–4. Of the 290 patients, 38.3% ( n = 111) had died within 2 years after surgery. Mortality among males was 46.3% ( n = 38) while mortality among females was 35,1% ( n = 73), p = 0.07. We found that on-admission Hb level <100 g/L was associated with 2-year mortality (HR = 3.3, 95% CI: 1.3–8.3, p < 0.01) while CRP >20 mg/L and serum creatinine >100 μmol/L were not associated with 2-year mortality ( p = 0.89 and p = 0.31, respectively). Conclusion On-admission Hb level <100 g/L, but not CRP >20 mg/L and serum creatinine >100 μmol/L, was associated with 2-year mortality. These results can help healthcare providers identify high-risk FNF patients who probably would benefit from optimized perioperative medical management. |
url |
https://doi.org/10.1177/21514593211037758 |
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