New Complex Chromosomal Translocation in Chronic Myeloid Leukaemia: t(9;18;22)(q34;p11;q11)

New Complex Chromosomal Translocation in Chronic Myeloid Leukaemia: t(9;18;22)(q34;p11;q11)

A Chronic myeloid leukaemia (CML) case with a new complex t(9;18;22)(q34;p11;q11) of a 29-year-old man is being reported. For the first time, this translocation has been characterized by karyotype complemented with fluorescence in situ hybridization (FISH). In CML, the complex and standard translo...

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Main Authors: Abdeljabar El Andaloussi, Chrystele Bilhou-Nabera
Format: Article
Language:English
Published: Hindawi Limited 2007-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2007/92385
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spelling doaj-246fa6f3cb9b4a6db936c625de4e794f2020-11-25T01:35:52ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512007-01-01200710.1155/2007/9238592385New Complex Chromosomal Translocation in Chronic Myeloid Leukaemia: t(9;18;22)(q34;p11;q11)Abdeljabar El Andaloussi0Chrystele Bilhou-Nabera1Laboratoire de Cytogénétique, Institut Pasteur du Maroc, Casablanca 20100, MoroccoLaboratoire d'Hématologie-Pr RAPHAEL, Cytogénétique, Pav BROCA - 4ème étage, 78 rue du Général Leclerc, Le Kremlin-Bicetre 94275, FranceA Chronic myeloid leukaemia (CML) case with a new complex t(9;18;22)(q34;p11;q11) of a 29-year-old man is being reported. For the first time, this translocation has been characterized by karyotype complemented with fluorescence in situ hybridization (FISH). In CML, the complex and standard translocations have the same prognosis. The patient was treated with standard initial therapy based on hydroxyurea before he died due to heart failure four months later. Our finding indicates the importance of combined cytogenetic analysis for diagnosis and guidance of treatment in clinical diagnosis of CML.http://dx.doi.org/10.1155/2007/92385
collection DOAJ
language English
format Article
sources DOAJ
author Abdeljabar El Andaloussi
Chrystele Bilhou-Nabera
spellingShingle Abdeljabar El Andaloussi
Chrystele Bilhou-Nabera
New Complex Chromosomal Translocation in Chronic Myeloid Leukaemia: t(9;18;22)(q34;p11;q11)
Journal of Biomedicine and Biotechnology
author_facet Abdeljabar El Andaloussi
Chrystele Bilhou-Nabera
author_sort Abdeljabar El Andaloussi
title New Complex Chromosomal Translocation in Chronic Myeloid Leukaemia: t(9;18;22)(q34;p11;q11)
title_short New Complex Chromosomal Translocation in Chronic Myeloid Leukaemia: t(9;18;22)(q34;p11;q11)
title_full New Complex Chromosomal Translocation in Chronic Myeloid Leukaemia: t(9;18;22)(q34;p11;q11)
title_fullStr New Complex Chromosomal Translocation in Chronic Myeloid Leukaemia: t(9;18;22)(q34;p11;q11)
title_full_unstemmed New Complex Chromosomal Translocation in Chronic Myeloid Leukaemia: t(9;18;22)(q34;p11;q11)
title_sort new complex chromosomal translocation in chronic myeloid leukaemia: t(9;18;22)(q34;p11;q11)
publisher Hindawi Limited
series Journal of Biomedicine and Biotechnology
issn 1110-7243
1110-7251
publishDate 2007-01-01
description A Chronic myeloid leukaemia (CML) case with a new complex t(9;18;22)(q34;p11;q11) of a 29-year-old man is being reported. For the first time, this translocation has been characterized by karyotype complemented with fluorescence in situ hybridization (FISH). In CML, the complex and standard translocations have the same prognosis. The patient was treated with standard initial therapy based on hydroxyurea before he died due to heart failure four months later. Our finding indicates the importance of combined cytogenetic analysis for diagnosis and guidance of treatment in clinical diagnosis of CML.
url http://dx.doi.org/10.1155/2007/92385
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AT chrystelebilhounabera newcomplexchromosomaltranslocationinchronicmyeloidleukaemiat91822q34p11q11
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