Disease progression velocity as predictor of severity in Guillain-Barre syndrome
Objective: To identify the velocity of disease progression as a predictor of severity in patients with Guillain-Barre syndrome (GBS). Materials and methods: Prospective observational study of patients with confirmed diagnosis of GBS between May and August 2019 in four hospitals in Peru. The disease...
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Instituto Nacional de Salud
2021-03-01
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doaj-2472547200984bb5bb1ee5a6d7b3f2f82021-05-11T21:46:25ZspaInstituto Nacional de SaludRevista Peruana de Medicina Experimental y Salud Pública1726-46341726-46422021-03-01381172310.17843/rpmesp.2021.381.51062487Disease progression velocity as predictor of severity in Guillain-Barre syndromeRaúl Montalvo0Alex Castañeda1Jorge A. López2Cecilia Mathey3Facultad de Medicina Humana, Universidad Nacional del Centro del Perú, Huancayo, Perú. Médico/a cirujano/a; especialista en Enfermedades Infecciosas y TropicalesServicio de Enfermedades Infecciosas y Tropicales, Hospital Lazarte, Trujillo, Perú. Médico/a cirujano/a; especialista en Enfermedades Infecciosas y TropicalesFacultad de Medicina Humana, Universidad Nacional del Centro del Perú, Huancayo, Perú. Médico/a cirujano/a; especialista en Radiología y Diagnóstico por imágenes.Servicio de Enfermedades Infecciosas y Tropicales, Hospital Daniel A. Carrión, Huancayo, Perú. Médico/a cirujano/a; especialista en Enfermedades Infecciosas y TropicalesObjective: To identify the velocity of disease progression as a predictor of severity in patients with Guillain-Barre syndrome (GBS). Materials and methods: Prospective observational study of patients with confirmed diagnosis of GBS between May and August 2019 in four hospitals in Peru. The disease progression velocity (DPV) was defined as the time since the onset of neurological symptoms and the maximum peak of neurological severity. Results: Of 94 cases with GBS, the average age was 42 years; 73 (77.8%) patients presented severe GBS, the average hospital stay was 19 days; 45 (47.8%) patients had diarrheal symptoms previously, in 63 (67.1%) patients the onset of motor weakness was located in the upper limbs and in 31 (32.9%) it was located in the lower limbs, 9 (10.0%) patients presented some type of dysautonomy; admission to mechanical ventilation was needed in 8 (8.5%) patients, and the deceased were 2 (2.0%). The DPV≤ 1 day has a 79% probability of developing severe disease, the two and three day DPV have the probability of 61% and 38% respectively of progressing to severe forms. Conclusion: DPV is a predictor of poor prognosis when it is less than 2 days and with a possible requirement for mechanical ventilation. The speed of progression of neurological disease is a practical and accessible clinical evaluation method that should be evaluated in patients with GBS.https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/5106síndrome de guillain-barrépronósticoíndice de severidad de la enfermedadprogresión de la enfermedad |
collection |
DOAJ |
language |
Spanish |
format |
Article |
sources |
DOAJ |
author |
Raúl Montalvo Alex Castañeda Jorge A. López Cecilia Mathey |
spellingShingle |
Raúl Montalvo Alex Castañeda Jorge A. López Cecilia Mathey Disease progression velocity as predictor of severity in Guillain-Barre syndrome Revista Peruana de Medicina Experimental y Salud Pública síndrome de guillain-barré pronóstico índice de severidad de la enfermedad progresión de la enfermedad |
author_facet |
Raúl Montalvo Alex Castañeda Jorge A. López Cecilia Mathey |
author_sort |
Raúl Montalvo |
title |
Disease progression velocity as predictor of severity in Guillain-Barre syndrome |
title_short |
Disease progression velocity as predictor of severity in Guillain-Barre syndrome |
title_full |
Disease progression velocity as predictor of severity in Guillain-Barre syndrome |
title_fullStr |
Disease progression velocity as predictor of severity in Guillain-Barre syndrome |
title_full_unstemmed |
Disease progression velocity as predictor of severity in Guillain-Barre syndrome |
title_sort |
disease progression velocity as predictor of severity in guillain-barre syndrome |
publisher |
Instituto Nacional de Salud |
series |
Revista Peruana de Medicina Experimental y Salud Pública |
issn |
1726-4634 1726-4642 |
publishDate |
2021-03-01 |
description |
Objective: To identify the velocity of disease progression as a predictor of severity in patients with Guillain-Barre syndrome (GBS). Materials and methods: Prospective observational study of patients with confirmed diagnosis of GBS between May and August 2019 in four hospitals in Peru. The disease progression velocity (DPV) was defined as the time since the onset of neurological symptoms and the maximum peak of neurological severity. Results: Of 94 cases with GBS, the average age was 42 years; 73 (77.8%) patients presented severe GBS, the average hospital stay was 19 days; 45 (47.8%) patients had diarrheal symptoms previously, in 63 (67.1%) patients the onset of motor weakness was located in the upper limbs and in 31 (32.9%) it was located in the lower limbs, 9 (10.0%) patients presented some type of dysautonomy; admission to mechanical ventilation was needed in 8 (8.5%) patients, and the deceased were 2 (2.0%). The DPV≤ 1 day has a 79% probability of developing severe disease, the two and three day DPV have the probability of 61% and 38% respectively of progressing to severe forms. Conclusion: DPV is a predictor of poor prognosis when it is less than 2 days and with a possible requirement for mechanical ventilation. The speed of progression of neurological disease is a practical and accessible clinical evaluation method that should be evaluated in patients with GBS. |
topic |
síndrome de guillain-barré pronóstico índice de severidad de la enfermedad progresión de la enfermedad |
url |
https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/5106 |
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