Successful intravenous thrombolysis in acute ischemic stroke after reversal of dabigatran etexilate with idarucizumab at the end of therapeutic time window
Dabigatran is a direct oral anticoagulant that is widely used for stroke prevention in patients with atrial fibrillation. We report a case of an 80-year-old stroke patient on dabigatran for permanent atrial fibrillation, who presented with an initial National Institutes of Health Stroke Scale (NIHSS...
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Wolters Kluwer Medknow Publications
2020-01-01
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doaj-2477d3d339d949b6be899531f7a13ea92021-02-03T07:13:14ZengWolters Kluwer Medknow PublicationsTurkish Journal of Emergency Medicine2452-24732452-24732020-01-01202909210.4103/2452-2473.285015Successful intravenous thrombolysis in acute ischemic stroke after reversal of dabigatran etexilate with idarucizumab at the end of therapeutic time windowGorana VukorepaSabina Deveđija*Miljenko CrnjakovićMirna KarakašZeljka CukDabigatran is a direct oral anticoagulant that is widely used for stroke prevention in patients with atrial fibrillation. We report a case of an 80-year-old stroke patient on dabigatran for permanent atrial fibrillation, who presented with an initial National Institutes of Health Stroke Scale (NIHSS) of 8. Dabigatran was reversed with idarucizumab, and intravenous tissue-type plasminogen activator (IV-tPA) was administrated beginning 4 h and 28 min after the symptom onset. The patient was discharged with an NIHSS of 1. Our case is an additional proof of safety and efficiency of idarucizumab in the clinical setting of ischemic stroke before the administration of IV-tPA.http://www.turkjemergmed.org/article.asp?issn=2452-2473;year=2020;volume=20;issue=2;spage=90;epage=92;aulast=Vukorepaacute ischemic strokeacute stroke therapyanticoagulantsdabigatranidarucizumabthrombolysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gorana Vukorepa Sabina Deveđija* Miljenko Crnjaković Mirna Karakaš Zeljka Cuk |
spellingShingle |
Gorana Vukorepa Sabina Deveđija* Miljenko Crnjaković Mirna Karakaš Zeljka Cuk Successful intravenous thrombolysis in acute ischemic stroke after reversal of dabigatran etexilate with idarucizumab at the end of therapeutic time window Turkish Journal of Emergency Medicine acute ischemic stroke acute stroke therapy anticoagulants dabigatran idarucizumab thrombolysis |
author_facet |
Gorana Vukorepa Sabina Deveđija* Miljenko Crnjaković Mirna Karakaš Zeljka Cuk |
author_sort |
Gorana Vukorepa |
title |
Successful intravenous thrombolysis in acute ischemic stroke after reversal of dabigatran etexilate with idarucizumab at the end of therapeutic time window |
title_short |
Successful intravenous thrombolysis in acute ischemic stroke after reversal of dabigatran etexilate with idarucizumab at the end of therapeutic time window |
title_full |
Successful intravenous thrombolysis in acute ischemic stroke after reversal of dabigatran etexilate with idarucizumab at the end of therapeutic time window |
title_fullStr |
Successful intravenous thrombolysis in acute ischemic stroke after reversal of dabigatran etexilate with idarucizumab at the end of therapeutic time window |
title_full_unstemmed |
Successful intravenous thrombolysis in acute ischemic stroke after reversal of dabigatran etexilate with idarucizumab at the end of therapeutic time window |
title_sort |
successful intravenous thrombolysis in acute ischemic stroke after reversal of dabigatran etexilate with idarucizumab at the end of therapeutic time window |
publisher |
Wolters Kluwer Medknow Publications |
series |
Turkish Journal of Emergency Medicine |
issn |
2452-2473 2452-2473 |
publishDate |
2020-01-01 |
description |
Dabigatran is a direct oral anticoagulant that is widely used for stroke prevention in patients with atrial fibrillation. We report a case of an 80-year-old stroke patient on dabigatran for permanent atrial fibrillation, who presented with an initial National Institutes of Health Stroke Scale (NIHSS) of 8. Dabigatran was reversed with idarucizumab, and intravenous tissue-type plasminogen activator (IV-tPA) was administrated beginning 4 h and 28 min after the symptom onset. The patient was discharged with an NIHSS of 1. Our case is an additional proof of safety and efficiency of idarucizumab in the clinical setting of ischemic stroke before the administration of IV-tPA. |
topic |
acute ischemic stroke acute stroke therapy anticoagulants dabigatran idarucizumab thrombolysis |
url |
http://www.turkjemergmed.org/article.asp?issn=2452-2473;year=2020;volume=20;issue=2;spage=90;epage=92;aulast=Vukorepa |
work_keys_str_mv |
AT goranavukorepa successfulintravenousthrombolysisinacuteischemicstrokeafterreversalofdabigatranetexilatewithidarucizumabattheendoftherapeutictimewindow AT sabinadeveđija successfulintravenousthrombolysisinacuteischemicstrokeafterreversalofdabigatranetexilatewithidarucizumabattheendoftherapeutictimewindow AT miljenkocrnjakovic successfulintravenousthrombolysisinacuteischemicstrokeafterreversalofdabigatranetexilatewithidarucizumabattheendoftherapeutictimewindow AT mirnakarakas successfulintravenousthrombolysisinacuteischemicstrokeafterreversalofdabigatranetexilatewithidarucizumabattheendoftherapeutictimewindow AT zeljkacuk successfulintravenousthrombolysisinacuteischemicstrokeafterreversalofdabigatranetexilatewithidarucizumabattheendoftherapeutictimewindow |
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