Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?

A number of immune regulatory cellular therapies, including regulatory T cells and mesenchymal stromal cells, have emerged as novel alternative therapies for the control of transplant alloresponses. Clinical studies have demonstrated their feasibility and safety, however developing our understanding...

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Main Authors:	Helen L. Stark, Hayson C. Wang, Jasmina Kuburic, Alaa Alzhrani, Joanna Hester, Fadi Issa
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Series:	Frontiers in Immunology
Subjects:	immune monitoring cell therapy transplantation regulatory T cell mesenchymal stromal cell
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.664244/full

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spelling	doaj-248b10c96750418c8ed10ec88fd081b42021-03-25T08:58:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-03-011210.3389/fimmu.2021.664244664244Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?Helen L. Stark0Hayson C. Wang1Hayson C. Wang2Jasmina Kuburic3Alaa Alzhrani4Joanna Hester5Fadi Issa6Transplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United KingdomTransplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United KingdomDivision of Plastic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaTransplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United KingdomTransplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United KingdomTransplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United KingdomTransplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United KingdomA number of immune regulatory cellular therapies, including regulatory T cells and mesenchymal stromal cells, have emerged as novel alternative therapies for the control of transplant alloresponses. Clinical studies have demonstrated their feasibility and safety, however developing our understanding of the impact of cellular therapeutics in vivo requires advanced immune monitoring strategies. To accurately monitor the immune response, a combination of complementary methods is required to measure the cellular and molecular phenotype as well as the function of cells involved. In this review we focus on the current immune monitoring strategies and discuss which methods may be utilized in the future.https://www.frontiersin.org/articles/10.3389/fimmu.2021.664244/fullimmune monitoringcell therapytransplantationregulatory T cellmesenchymal stromal cell
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Helen L. Stark Hayson C. Wang Hayson C. Wang Jasmina Kuburic Alaa Alzhrani Joanna Hester Fadi Issa
spellingShingle	Helen L. Stark Hayson C. Wang Hayson C. Wang Jasmina Kuburic Alaa Alzhrani Joanna Hester Fadi Issa Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When? Frontiers in Immunology immune monitoring cell therapy transplantation regulatory T cell mesenchymal stromal cell
author_facet	Helen L. Stark Hayson C. Wang Hayson C. Wang Jasmina Kuburic Alaa Alzhrani Joanna Hester Fadi Issa
author_sort	Helen L. Stark
title	Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?
title_short	Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?
title_full	Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?
title_fullStr	Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?
title_full_unstemmed	Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?
title_sort	immune monitoring for advanced cell therapy trials in transplantation: which assays and when?
publisher	Frontiers Media S.A.
series	Frontiers in Immunology
issn	1664-3224
publishDate	2021-03-01
description	A number of immune regulatory cellular therapies, including regulatory T cells and mesenchymal stromal cells, have emerged as novel alternative therapies for the control of transplant alloresponses. Clinical studies have demonstrated their feasibility and safety, however developing our understanding of the impact of cellular therapeutics in vivo requires advanced immune monitoring strategies. To accurately monitor the immune response, a combination of complementary methods is required to measure the cellular and molecular phenotype as well as the function of cells involved. In this review we focus on the current immune monitoring strategies and discuss which methods may be utilized in the future.
topic	immune monitoring cell therapy transplantation regulatory T cell mesenchymal stromal cell
url	https://www.frontiersin.org/articles/10.3389/fimmu.2021.664244/full
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Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?

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