Low dose dexamethasone as treatment for women with heavy menstrual bleeding: A response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM)

Low dose dexamethasone as treatment for women with heavy menstrual bleeding: A response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM)

Background: The symptom of heavy menstrual bleeding (HMB) diminishes quality-of-life for many mid-age women and imposes substantial societal burden. We investigated our hypothesis that HMB reflects impaired endometrial vasoconstriction due to endometrial glucocorticoid deficiency. Does reversing thi...

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Bibliographic Details
Main Authors: Pamela Warner, Lucy Harriet Ravenscroft Whitaker, Richard Anthony Parker, Christopher John Weir, Anne Douglas, Christian Holm Hansen, Mayank Madhra, Stephen Gilbert Hillier, Philippa Tansy Kemp Saunders, John Peter Iredale, Scott Semple, Ov Daniel Slayden, Brian Robert Walker, Hilary Octavia Dawn Critchley
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:EBioMedicine
Subjects:
Heavy menstrual bleeding (HMB)
Randomised controlled trial
Dexamethasone
Adaptive randomisation
Endometrium
Bayesian
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421002279

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