The Frequency of Cerebral Microembolism in Acute Myocardial Infarction

• Main Authors: Masoud Mehrpour, Babak Zamani, Hamid R Baradaran, Mohamad R Motamed
• Format: Article
• Language: English
• Published: Iran University of Medical Sciences 2010-11-01
• Series: Basic and Clinical Neuroscience
• Subjects: Microembilism; Stroke; Streptokinase
• Online Access: http://bcn.iums.ac.ir/browse.php?a_code=A-10-2-10&slc_lang=en&sid=1

ABSTRACT Introduction: Stroke is more common in patients with cerebral microembolisms. Frequency of cerebral microembolisms (high intensity transient signals, HITS) in acute myocardial infarction has been reported about 17%. The factors that influence on microembolism after myocardial infarction (MI) are not definitive. Type of MI, Ejection fraction, Hx of Streptokinase is the factors that were studied. Methods: During three years we studied the frequency of cerebral microembolisms in AMI patients, we studied forty patients with microembolism as a case group and ninety patients without microembolism as a control group. We detected microembolism in patients by transcranial doppler study within 72 houre after myocardial infarction. Two-dimensional echocardiogram was performed for all patients during hospitalization. Excluding criteria were prosthetic heart valves, carotid stenosis >50% and poor window for TCD monitoring. Results: number of patients who had history of receiving SK were significantly more common in case group in comparison to control group. OR 2.4 CI(1.1-5.2) The frequency was more prevalent in anterolateral MI in comparison to inferior MI.OR=3.3 CI(1.4-7.4). Ejection fraction has no significant effect on frequency of microembolism. OR 0.5 CI(0.2-1.3).Hypokinesia is also a risk factor for increasing risk of microembolism. OR 4.5 CI(1.4.13.8) Discussion: frequency of microembolism has been increased in patients with history of streptokinase or in the type of Anterolateral MI or wall motion abnormality, so we should be careful for risk of microembolism in this groups.