Restricted Water Diffusion in Diffusion-Weighted Magnetic Resonance Imaging in Pancreatic Cancer is Associated with Tumor Hypoxia

Restricted Water Diffusion in Diffusion-Weighted Magnetic Resonance Imaging in Pancreatic Cancer is Associated with Tumor Hypoxia

Hypoxia is a hallmark of pancreatic cancer (PDAC) due to its compact and extensive fibrotic tumor stroma. Hypoxia contributes to high lethality of this disease, by inducing a more malignant phenotype and resistance to radiation and chemotherapy. Thus, non-invasive methods to quantify hypoxia could b...

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Bibliographic Details
Main Authors: Philipp Mayer, Anne Kraft, Hagen R. Witzel, Nicole Marnet, Nina Hörner, Wilfried Roth, Stefan Heinrich, Thilo Hackert, Frank Bergmann, Hans-Ulrich Kauczor, Miriam Klauss, Matthias M. Gaida
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
hypoxia
diffusion-weighted imaging.
Online Access:https://www.mdpi.com/2072-6694/13/1/89

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