Disseminated infection by Mycobacterium genavense in an HIV-1 infected patient
Opportunistic infections are an important cause of death and morbidity among HIV infected patients. Disseminated infections by nontuberculous mycobacteria are a diagnostic to consider among these patients with a high level of immunosuppression.A 64 year old Caucasian man, born in Angola, living in P...
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doaj-249e08dd9d0449d0a969cabfbfc54f912021-07-02T09:09:34ZengElsevierIDCases2214-25092020-01-0121e00926Disseminated infection by Mycobacterium genavense in an HIV-1 infected patientTomás Robalo Nunes0Ana Calderón1Clara Barroso2Nuno Marques3Infectious Diseases Resident, Infectious Diseases Department, Hospital Garcia de Orta, Almada, Portugal; Corresponding author at: Infectious Diseases Department, Hospital Garcia de Orta, Aveninda Torrado da Silva, Almada, 2805-267, Portugal.Pathology Resident, Histopathology Department, Hospital Garcia de Orta, Almada, PortugalConsultant in Pneumology, Centro de Diagnóstico Pneumológico, Almada, PortugalHead of Department of Infectious Diseases, Infectious Diseases Department, Hospital Garcia de Orta, Almada, PortugalOpportunistic infections are an important cause of death and morbidity among HIV infected patients. Disseminated infections by nontuberculous mycobacteria are a diagnostic to consider among these patients with a high level of immunosuppression.A 64 year old Caucasian man, born in Angola, living in Portugal since 1975, presented in the emergency room with generalized malaise, weight loss, vesperal temperatures of around 37.5 °C with night sweats for two months, and epigastric abdominal pain with liquid stools in the 2 previous weeks. Laboratory study revealed a previously undiagnosed HIV-1 infection with 42 Lymphocytes CD4+/uL and viremia of 61,249 copies/mL. The abdominal-pelvic CT scan showed multiple necrotic ganglia in the mesenterium and mesenteric vases, which were biopsied revealing positive PCR for a nontuberculous mycobacteria; duodenal biopsies showed similar results. The bone marrow blood culture yeald the growth of Mycobacterium genavense. Antimicobacterial treatment was started and after six months he showed imagiological deterioration and the antibiogram revealed resistance to all antimycobacterial agents. The therapeutic scheme was empirically changed and the patient kept under vigilance with chronic therapy.This rare clinical case is both a diagnostic and therapeutic challenge.http://www.sciencedirect.com/science/article/pii/S2214250920302341Mycobacterium genavenseHIV infectionOpportunistic infections |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tomás Robalo Nunes Ana Calderón Clara Barroso Nuno Marques |
spellingShingle |
Tomás Robalo Nunes Ana Calderón Clara Barroso Nuno Marques Disseminated infection by Mycobacterium genavense in an HIV-1 infected patient IDCases Mycobacterium genavense HIV infection Opportunistic infections |
author_facet |
Tomás Robalo Nunes Ana Calderón Clara Barroso Nuno Marques |
author_sort |
Tomás Robalo Nunes |
title |
Disseminated infection by Mycobacterium genavense in an HIV-1 infected patient |
title_short |
Disseminated infection by Mycobacterium genavense in an HIV-1 infected patient |
title_full |
Disseminated infection by Mycobacterium genavense in an HIV-1 infected patient |
title_fullStr |
Disseminated infection by Mycobacterium genavense in an HIV-1 infected patient |
title_full_unstemmed |
Disseminated infection by Mycobacterium genavense in an HIV-1 infected patient |
title_sort |
disseminated infection by mycobacterium genavense in an hiv-1 infected patient |
publisher |
Elsevier |
series |
IDCases |
issn |
2214-2509 |
publishDate |
2020-01-01 |
description |
Opportunistic infections are an important cause of death and morbidity among HIV infected patients. Disseminated infections by nontuberculous mycobacteria are a diagnostic to consider among these patients with a high level of immunosuppression.A 64 year old Caucasian man, born in Angola, living in Portugal since 1975, presented in the emergency room with generalized malaise, weight loss, vesperal temperatures of around 37.5 °C with night sweats for two months, and epigastric abdominal pain with liquid stools in the 2 previous weeks. Laboratory study revealed a previously undiagnosed HIV-1 infection with 42 Lymphocytes CD4+/uL and viremia of 61,249 copies/mL. The abdominal-pelvic CT scan showed multiple necrotic ganglia in the mesenterium and mesenteric vases, which were biopsied revealing positive PCR for a nontuberculous mycobacteria; duodenal biopsies showed similar results. The bone marrow blood culture yeald the growth of Mycobacterium genavense. Antimicobacterial treatment was started and after six months he showed imagiological deterioration and the antibiogram revealed resistance to all antimycobacterial agents. The therapeutic scheme was empirically changed and the patient kept under vigilance with chronic therapy.This rare clinical case is both a diagnostic and therapeutic challenge. |
topic |
Mycobacterium genavense HIV infection Opportunistic infections |
url |
http://www.sciencedirect.com/science/article/pii/S2214250920302341 |
work_keys_str_mv |
AT tomasrobalonunes disseminatedinfectionbymycobacteriumgenavenseinanhiv1infectedpatient AT anacalderon disseminatedinfectionbymycobacteriumgenavenseinanhiv1infectedpatient AT clarabarroso disseminatedinfectionbymycobacteriumgenavenseinanhiv1infectedpatient AT nunomarques disseminatedinfectionbymycobacteriumgenavenseinanhiv1infectedpatient |
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1721333375766102016 |