A standardized notoginseng extract exerts cardioprotection by attenuating apoptosis under endoplasmic reticulum stress conditions

A standardized notoginseng extract exerts cardioprotection by attenuating apoptosis under endoplasmic reticulum stress conditions

Panax notoginseng possesses therapeutic potential for cardiovascular disorders. Endoplasmic reticulum (ER) stress plays a critical role in cardiovascular disease. Here we show that a rare ginsenoside-standardized extract (RGSE) from notoginseng exerts cardioprotection via attenuating ER stress-assoc...

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Main Authors: Li-Chao Wang, Wen-Song Zhang, Qun Liu, Jia Li, Raphael N. Alolga, Kang Liu, Bao-Lin Liu, Ping Li, Lian-Wen Qi
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Journal of Functional Foods
Subjects:
Acute myocardial infarction
Apoptosis
Cardioprotection
Endoplasmic reticulum stress
Rare ginsenoside-standardized extract
Steamed Panax notoginseng
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464615001917
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spelling doaj-24a3e14198584766ae91cd9e042a59e82021-04-29T04:44:22ZengElsevierJournal of Functional Foods1756-46462015-06-01162027A standardized notoginseng extract exerts cardioprotection by attenuating apoptosis under endoplasmic reticulum stress conditionsLi-Chao Wang0Wen-Song Zhang1Qun Liu2Jia Li3Raphael N. Alolga4Kang Liu5Bao-Lin Liu6Ping Li7Lian-Wen Qi8State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, ChinaState Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, ChinaState Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, ChinaDepartment of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, ChinaState Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, ChinaDepartment of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, ChinaDepartment of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, ChinaState Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, China; Corresponding author. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Tel.: +86 25 83271379; fax: +86 25 83271379.State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, China; Corresponding author. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Tel.: +86 25 83271379; fax: +86 25 83271379.Panax notoginseng possesses therapeutic potential for cardiovascular disorders. Endoplasmic reticulum (ER) stress plays a critical role in cardiovascular disease. Here we show that a rare ginsenoside-standardized extract (RGSE) from notoginseng exerts cardioprotection via attenuating ER stress-associated apoptosis. A total of 18 ginsenosides with a concentration of 816.75 mg/g were characterized and quantified in RGSE. Ginsenoside Rh4, Rg5, Rk3, and Rk1 were the most abundant. RGSE at 50 and 100 mg/kg significantly attenuated myocardial infarction and improved cardiac function in acute myocardial infarction (AMI). RGSE also prevented myocardial ischemia-induced oxidative stress and apoptosis in vivo and in vitro. In addition, RGSE decreased the overexpression of GRP78, GRP94 and CHOP, and inhibited the phosphorylation of PERK and IRE1α in ER stress. Further investigation revealed that RGSE effectually inactivated TXNIP/NLRP3 signaling pathway in AMI hearts. These observations suggest a novel role for notoginseng in regulating AMI.http://www.sciencedirect.com/science/article/pii/S1756464615001917Acute myocardial infarctionApoptosisCardioprotectionEndoplasmic reticulum stressRare ginsenoside-standardized extractSteamed Panax notoginseng
collection DOAJ
language English
format Article
sources DOAJ
author Li-Chao Wang
Wen-Song Zhang
Qun Liu
Jia Li
Raphael N. Alolga
Kang Liu
Bao-Lin Liu
Ping Li
Lian-Wen Qi
spellingShingle Li-Chao Wang
Wen-Song Zhang
Qun Liu
Jia Li
Raphael N. Alolga
Kang Liu
Bao-Lin Liu
Ping Li
Lian-Wen Qi
A standardized notoginseng extract exerts cardioprotection by attenuating apoptosis under endoplasmic reticulum stress conditions
Journal of Functional Foods
Acute myocardial infarction
Apoptosis
Cardioprotection
Endoplasmic reticulum stress
Rare ginsenoside-standardized extract
Steamed Panax notoginseng
author_facet Li-Chao Wang
Wen-Song Zhang
Qun Liu
Jia Li
Raphael N. Alolga
Kang Liu
Bao-Lin Liu
Ping Li
Lian-Wen Qi
author_sort Li-Chao Wang
title A standardized notoginseng extract exerts cardioprotection by attenuating apoptosis under endoplasmic reticulum stress conditions
title_short A standardized notoginseng extract exerts cardioprotection by attenuating apoptosis under endoplasmic reticulum stress conditions
title_full A standardized notoginseng extract exerts cardioprotection by attenuating apoptosis under endoplasmic reticulum stress conditions
title_fullStr A standardized notoginseng extract exerts cardioprotection by attenuating apoptosis under endoplasmic reticulum stress conditions
title_full_unstemmed A standardized notoginseng extract exerts cardioprotection by attenuating apoptosis under endoplasmic reticulum stress conditions
title_sort standardized notoginseng extract exerts cardioprotection by attenuating apoptosis under endoplasmic reticulum stress conditions
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2015-06-01
description Panax notoginseng possesses therapeutic potential for cardiovascular disorders. Endoplasmic reticulum (ER) stress plays a critical role in cardiovascular disease. Here we show that a rare ginsenoside-standardized extract (RGSE) from notoginseng exerts cardioprotection via attenuating ER stress-associated apoptosis. A total of 18 ginsenosides with a concentration of 816.75 mg/g were characterized and quantified in RGSE. Ginsenoside Rh4, Rg5, Rk3, and Rk1 were the most abundant. RGSE at 50 and 100 mg/kg significantly attenuated myocardial infarction and improved cardiac function in acute myocardial infarction (AMI). RGSE also prevented myocardial ischemia-induced oxidative stress and apoptosis in vivo and in vitro. In addition, RGSE decreased the overexpression of GRP78, GRP94 and CHOP, and inhibited the phosphorylation of PERK and IRE1α in ER stress. Further investigation revealed that RGSE effectually inactivated TXNIP/NLRP3 signaling pathway in AMI hearts. These observations suggest a novel role for notoginseng in regulating AMI.
topic Acute myocardial infarction
Apoptosis
Cardioprotection
Endoplasmic reticulum stress
Rare ginsenoside-standardized extract
Steamed Panax notoginseng
url http://www.sciencedirect.com/science/article/pii/S1756464615001917
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