Inhibitory Activity of Pyrroloisoxazolidine Derivatives against Chlamydia trachomatis
The obligate intracellular bacterium Chlamydia trachomatis is a group of worldwide human pathogens that can lead to serious reproductive problems. The frequent clinical treatment failure promoted the development of novel antichlamydial agents. Here, we firstly reported a group of pyrroloisoxazolidin...
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2021-01-01
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Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2021/8889247 |
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doaj-24a4021da9f340dc9d60eba1ed757ebb2021-03-29T00:08:47ZengHindawi LimitedBioMed Research International2314-61412021-01-01202110.1155/2021/8889247Inhibitory Activity of Pyrroloisoxazolidine Derivatives against Chlamydia trachomatisMin Ni0Shunxin Xu1Ziyi Liu2Yin Xue3Wenxia Xie4Shengju Yang5Lingyan Liu6Xiaofeng Bao7School of PharmacySchool of PharmacySchool of PharmacySchool of PharmacySchool of PharmacyDepartment of Dermatology and VenereologyState Key Laboratory of Elemento-Organic ChemsitrySchool of PharmacyThe obligate intracellular bacterium Chlamydia trachomatis is a group of worldwide human pathogens that can lead to serious reproductive problems. The frequent clinical treatment failure promoted the development of novel antichlamydial agents. Here, we firstly reported a group of pyrroloisoxazolidine-inhibited C. trachomatis in a dose-dependent manner in vitro. Among them, compounds 1 and 2 exhibited the strongest inhibitory activity with IC50 values from 7.25 to 9.73 μM. The compounds disturbed the whole intracellular life cycle of C. trachomatis, mainly targeting the middle reticulate body proliferation stages. Besides, the compounds partially inhibited the chlamydial infection by reducing elementary body infectivity at high concentration. Our findings suggest the potential of pyrroloisoxazolidine derivatives as promising lead molecules for the development of antichlamydial agents.http://dx.doi.org/10.1155/2021/8889247 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Min Ni Shunxin Xu Ziyi Liu Yin Xue Wenxia Xie Shengju Yang Lingyan Liu Xiaofeng Bao |
spellingShingle |
Min Ni Shunxin Xu Ziyi Liu Yin Xue Wenxia Xie Shengju Yang Lingyan Liu Xiaofeng Bao Inhibitory Activity of Pyrroloisoxazolidine Derivatives against Chlamydia trachomatis BioMed Research International |
author_facet |
Min Ni Shunxin Xu Ziyi Liu Yin Xue Wenxia Xie Shengju Yang Lingyan Liu Xiaofeng Bao |
author_sort |
Min Ni |
title |
Inhibitory Activity of Pyrroloisoxazolidine Derivatives against Chlamydia trachomatis |
title_short |
Inhibitory Activity of Pyrroloisoxazolidine Derivatives against Chlamydia trachomatis |
title_full |
Inhibitory Activity of Pyrroloisoxazolidine Derivatives against Chlamydia trachomatis |
title_fullStr |
Inhibitory Activity of Pyrroloisoxazolidine Derivatives against Chlamydia trachomatis |
title_full_unstemmed |
Inhibitory Activity of Pyrroloisoxazolidine Derivatives against Chlamydia trachomatis |
title_sort |
inhibitory activity of pyrroloisoxazolidine derivatives against chlamydia trachomatis |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6141 |
publishDate |
2021-01-01 |
description |
The obligate intracellular bacterium Chlamydia trachomatis is a group of worldwide human pathogens that can lead to serious reproductive problems. The frequent clinical treatment failure promoted the development of novel antichlamydial agents. Here, we firstly reported a group of pyrroloisoxazolidine-inhibited C. trachomatis in a dose-dependent manner in vitro. Among them, compounds 1 and 2 exhibited the strongest inhibitory activity with IC50 values from 7.25 to 9.73 μM. The compounds disturbed the whole intracellular life cycle of C. trachomatis, mainly targeting the middle reticulate body proliferation stages. Besides, the compounds partially inhibited the chlamydial infection by reducing elementary body infectivity at high concentration. Our findings suggest the potential of pyrroloisoxazolidine derivatives as promising lead molecules for the development of antichlamydial agents. |
url |
http://dx.doi.org/10.1155/2021/8889247 |
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