Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants

Background. Renal damage caused by drug toxicity is becoming increasingly common in the clinic. Preventing and treating kidney damage caused by drug toxicity are essential to maintain patient health and reduce the social and economic burden. In this study, we performed a meta-analysis to assess the...

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Main Authors: Shujun Lin, Wenshan Lin, Chunling Liao, Tianbiao Zhou
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2020/8819757
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spelling doaj-24ae70cbf9d24b88a242d4e9b7e1e5072021-01-04T00:00:22ZengHindawi LimitedStem Cells International1687-96782020-01-01202010.1155/2020/8819757Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by ToxicantsShujun Lin0Wenshan Lin1Chunling Liao2Tianbiao Zhou3Department of NephrologyDepartment of NephrologyDepartment of NephrologyDepartment of NephrologyBackground. Renal damage caused by drug toxicity is becoming increasingly common in the clinic. Preventing and treating kidney damage caused by drug toxicity are essential to maintain patient health and reduce the social and economic burden. In this study, we performed a meta-analysis to assess the nephroprotective effect of mesenchymal stem cells (MSCs) in the treatment of kidney disease induced by toxicants. Methods. The Cochrane Library, Embase, ISI Web of Science, and PubMed databases were searched up to December 31, 2019, to identify studies and extract data to assess the efficacy of MSCs treatment of kidney disease induced by toxicants using Cochrane Review Manager Version 5.3. A total of 27 studies were eligible and selected for this meta-analysis. Results. The results showed that a difference in serum creatinine levels between the MSC treatment group and control group was observed for 2, 4, 5, 6-8, 10-15, 28-30, and ≥42 days (2 days: WMD=−0.88, 95% CI: -1.34, -0.42, P=0.0002; 4 days: WMD=−0.74, 95% CI: -0.95, -0.54, P<0.00001; 5 days: WMD=−0.46, 95% CI: -0.67, -0.25, P<0.0001; 6-8 days: WMD=−0.55, 95% CI: -0.84, -0.26, P=0.0002; 10-15 days: WMD=−0.37, 95% CI: -0.53, -0.20, P<0.0001; 28-30 days: WMD=−0.53, 95% CI: -1.04, -0.02, P=0.04; ≥42 days: WMD=−0.22, 95% CI: -0.39, -0.06, P=0.007). Furthermore, a difference in blood urea nitrogen levels between the MSC treatment group and control group was observed for 2-3, 4-5, 6-8, and ≥28 days. The results also indicate that MSC treatment alleviated inflammatory cells, necrotic tubules, regenerative tubules, and renal interstitial fibrosis in kidney disease induced by toxicants. Conclusion. MSCs may be a promising therapeutic agent for kidney disease induced by toxicants.http://dx.doi.org/10.1155/2020/8819757
collection DOAJ
language English
format Article
sources DOAJ
author Shujun Lin
Wenshan Lin
Chunling Liao
Tianbiao Zhou
spellingShingle Shujun Lin
Wenshan Lin
Chunling Liao
Tianbiao Zhou
Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants
Stem Cells International
author_facet Shujun Lin
Wenshan Lin
Chunling Liao
Tianbiao Zhou
author_sort Shujun Lin
title Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants
title_short Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants
title_full Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants
title_fullStr Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants
title_full_unstemmed Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants
title_sort nephroprotective effect of mesenchymal stem cell-based therapy of kidney disease induced by toxicants
publisher Hindawi Limited
series Stem Cells International
issn 1687-9678
publishDate 2020-01-01
description Background. Renal damage caused by drug toxicity is becoming increasingly common in the clinic. Preventing and treating kidney damage caused by drug toxicity are essential to maintain patient health and reduce the social and economic burden. In this study, we performed a meta-analysis to assess the nephroprotective effect of mesenchymal stem cells (MSCs) in the treatment of kidney disease induced by toxicants. Methods. The Cochrane Library, Embase, ISI Web of Science, and PubMed databases were searched up to December 31, 2019, to identify studies and extract data to assess the efficacy of MSCs treatment of kidney disease induced by toxicants using Cochrane Review Manager Version 5.3. A total of 27 studies were eligible and selected for this meta-analysis. Results. The results showed that a difference in serum creatinine levels between the MSC treatment group and control group was observed for 2, 4, 5, 6-8, 10-15, 28-30, and ≥42 days (2 days: WMD=−0.88, 95% CI: -1.34, -0.42, P=0.0002; 4 days: WMD=−0.74, 95% CI: -0.95, -0.54, P<0.00001; 5 days: WMD=−0.46, 95% CI: -0.67, -0.25, P<0.0001; 6-8 days: WMD=−0.55, 95% CI: -0.84, -0.26, P=0.0002; 10-15 days: WMD=−0.37, 95% CI: -0.53, -0.20, P<0.0001; 28-30 days: WMD=−0.53, 95% CI: -1.04, -0.02, P=0.04; ≥42 days: WMD=−0.22, 95% CI: -0.39, -0.06, P=0.007). Furthermore, a difference in blood urea nitrogen levels between the MSC treatment group and control group was observed for 2-3, 4-5, 6-8, and ≥28 days. The results also indicate that MSC treatment alleviated inflammatory cells, necrotic tubules, regenerative tubules, and renal interstitial fibrosis in kidney disease induced by toxicants. Conclusion. MSCs may be a promising therapeutic agent for kidney disease induced by toxicants.
url http://dx.doi.org/10.1155/2020/8819757
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