Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part I. The pathophysiology of thrombosis and hypercoagulation
Thrombosis is a fatal hemostatic disorders occurring in various conditions ranging from pregnancy and surgery to cancer, sepsis and heart attack. Despite the availability of different anticoagulants and accumulated clinical experience, proving their effectiveness, thrombosis remains a major cause of...
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doaj-24c3687f9f0943c6a8f8828a4733481b2021-07-29T09:03:05ZrusABV-pressOnkogematologiâ1818-83462015-10-01103737710.17650/1818-8346-2015-10-3-10-25171Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part I. The pathophysiology of thrombosis and hypercoagulationE. N. Lipets0F. I. Ataullakhanov1M. A. Panteleev2Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rоgachev; Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of SciencesFederal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rоgachev; Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of Sciences; HemaCore Company; M.V. Lomonosov Moscow State UniversityFederal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rоgachev; Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of Sciences; HemaCore Company; M.V. Lomonosov Moscow State UniversityThrombosis is a fatal hemostatic disorders occurring in various conditions ranging from pregnancy and surgery to cancer, sepsis and heart attack. Despite the availability of different anticoagulants and accumulated clinical experience, proving their effectiveness, thrombosis remains a major cause of morbidity and mortality. This is largely due to the fact that conventional laboratory coagulation tests are not sufficiently sensitive to the hypercoagulable state, and they are difficult to use for assessing the risk of thrombosis. Specific molecular markers (D-dimers, fibrinopeptide, thrombin-antithrombin complex) are more effective, but also have a large number of disadvantages. A possible solution is the use of integrated test, which simulate in vitro the majority of the physiological coagulation processes. In the first part of this paper the biochemical processes that cause the risk of thrombosis were discussed.https://oncohematology.abvpress.ru/ongm/article/view/157integral coagulation testshypercoagulationthrombosisd-dimersfibrinopeptideantithrombin complex |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
E. N. Lipets F. I. Ataullakhanov M. A. Panteleev |
spellingShingle |
E. N. Lipets F. I. Ataullakhanov M. A. Panteleev Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part I. The pathophysiology of thrombosis and hypercoagulation Onkogematologiâ integral coagulation tests hypercoagulation thrombosis d-dimers fibrinopeptide antithrombin complex |
author_facet |
E. N. Lipets F. I. Ataullakhanov M. A. Panteleev |
author_sort |
E. N. Lipets |
title |
Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part I. The pathophysiology of thrombosis and hypercoagulation |
title_short |
Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part I. The pathophysiology of thrombosis and hypercoagulation |
title_full |
Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part I. The pathophysiology of thrombosis and hypercoagulation |
title_fullStr |
Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part I. The pathophysiology of thrombosis and hypercoagulation |
title_full_unstemmed |
Integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. Part I. The pathophysiology of thrombosis and hypercoagulation |
title_sort |
integrated laboratory coagulation tests in hypercoagulation diagnosis and thrombosis risk assessment. part i. the pathophysiology of thrombosis and hypercoagulation |
publisher |
ABV-press |
series |
Onkogematologiâ |
issn |
1818-8346 |
publishDate |
2015-10-01 |
description |
Thrombosis is a fatal hemostatic disorders occurring in various conditions ranging from pregnancy and surgery to cancer, sepsis and heart attack. Despite the availability of different anticoagulants and accumulated clinical experience, proving their effectiveness, thrombosis remains a major cause of morbidity and mortality. This is largely due to the fact that conventional laboratory coagulation tests are not sufficiently sensitive to the hypercoagulable state, and they are difficult to use for assessing the risk of thrombosis. Specific molecular markers (D-dimers, fibrinopeptide, thrombin-antithrombin complex) are more effective, but also have a large number of disadvantages. A possible solution is the use of integrated test, which simulate in vitro the majority of the physiological coagulation processes. In the first part of this paper the biochemical processes that cause the risk of thrombosis were discussed. |
topic |
integral coagulation tests hypercoagulation thrombosis d-dimers fibrinopeptide antithrombin complex |
url |
https://oncohematology.abvpress.ru/ongm/article/view/157 |
work_keys_str_mv |
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