Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil
In the present study we surveyed the fauna of phlebotomine sand flies and small mammals in peridomestic areas from a Brazilian municipality where the American cutaneous leishmaniasis (ACL) is endemic. A total of 608 female phlebotomine sand flies were captured during nine months in 2009 and 2010. Se...
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doaj-24c939e06d514f00abae295736c32bed2020-11-25T00:10:19ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/592986592986Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in BrazilFabiana de Oliveira Lara-Silva0Ricardo Andrade Barata1Érika Monteiro Michalsky2Eduardo de Castro Ferreira3Maria Olímpia Garcia Lopes4Aimara da Costa Pinheiro5Consuelo Latorre Fortes-Dias6Edelberto Santos Dias7Laboratório de Leishmanioses, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, BrazilLaboratório de Parasitologia, Departamento de Ciências Biológicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, BrazilLaboratório de Leishmanioses, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, BrazilFundação Oswaldo Cruz, MS, BrazilBiodiversity Salvation, Belo Horizonte, MG, BrazilSecretaria Municipal de Saúde, Governador Valadares, MG, BrazilLaboratório de Enzimologia Aplicada, Diretoria de Pesquisa e Desenvolvimento, Fundação Ezequiel Dias, Belo Horizonte, MG, BrazilLaboratório de Leishmanioses, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, BrazilIn the present study we surveyed the fauna of phlebotomine sand flies and small mammals in peridomestic areas from a Brazilian municipality where the American cutaneous leishmaniasis (ACL) is endemic. A total of 608 female phlebotomine sand flies were captured during nine months in 2009 and 2010. Seven different species were represented with 60% of them being Lutzomyia intermedia and Lu. whitmani, both incriminated vectors of ACL. Lu. longipalpis, a proven vector of visceral leishmaniasis (VL) was also captured at high proportion (12.8%). Genomic DNA analysis of 136 species-specific pools of female sand flies followed by molecular genotyping showed the presence of Leishmania infantum DNA in two pools of Lu. longipalpis. The same Leishmania species was found in one blood sample from Rattus norvegicus among 119 blood and tissue samples analysed. This is the first report of Le. infantum in R. norvegicus in the Americas and suggests a possible role for this rodent species in the zoonotic cycle of VL. Our study coincided with the reemergence of VL in Governador Valadares.http://dx.doi.org/10.1155/2014/592986 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fabiana de Oliveira Lara-Silva Ricardo Andrade Barata Érika Monteiro Michalsky Eduardo de Castro Ferreira Maria Olímpia Garcia Lopes Aimara da Costa Pinheiro Consuelo Latorre Fortes-Dias Edelberto Santos Dias |
spellingShingle |
Fabiana de Oliveira Lara-Silva Ricardo Andrade Barata Érika Monteiro Michalsky Eduardo de Castro Ferreira Maria Olímpia Garcia Lopes Aimara da Costa Pinheiro Consuelo Latorre Fortes-Dias Edelberto Santos Dias Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil BioMed Research International |
author_facet |
Fabiana de Oliveira Lara-Silva Ricardo Andrade Barata Érika Monteiro Michalsky Eduardo de Castro Ferreira Maria Olímpia Garcia Lopes Aimara da Costa Pinheiro Consuelo Latorre Fortes-Dias Edelberto Santos Dias |
author_sort |
Fabiana de Oliveira Lara-Silva |
title |
Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil |
title_short |
Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil |
title_full |
Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil |
title_fullStr |
Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil |
title_full_unstemmed |
Rattus norvegicus (Rodentia: Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil |
title_sort |
rattus norvegicus (rodentia: muridae) infected by leishmania (leishmania) infantum (syn. le. chagasi) in brazil |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
In the present study we surveyed the fauna of phlebotomine sand flies and small mammals in peridomestic areas from a Brazilian municipality where the American cutaneous leishmaniasis (ACL) is endemic. A total of 608 female phlebotomine sand flies were captured during nine months in 2009 and 2010. Seven different species were represented with 60% of them being Lutzomyia intermedia and Lu. whitmani, both incriminated vectors of ACL. Lu. longipalpis, a proven vector of visceral leishmaniasis (VL) was also captured at high proportion (12.8%). Genomic DNA analysis of 136 species-specific pools of female sand flies followed by molecular genotyping showed the presence of Leishmania infantum DNA in two pools of Lu. longipalpis. The same Leishmania species was found in one blood sample from Rattus norvegicus among 119 blood and tissue samples analysed. This is the first report of Le. infantum in R. norvegicus in the Americas and suggests a possible role for this rodent species in the zoonotic cycle of VL. Our study coincided with the reemergence of VL in Governador Valadares. |
url |
http://dx.doi.org/10.1155/2014/592986 |
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