Overexpression of pyruvate dehydrogenase phosphatase 1 promotes the progression of pancreatic adenocarcinoma by regulating energy-related AMPK/mTOR signaling

Overexpression of pyruvate dehydrogenase phosphatase 1 promotes the progression of pancreatic adenocarcinoma by regulating energy-related AMPK/mTOR signaling

Abstract Background Human pyruvate dehydrogenase phosphatase 1 (PDP1) plays an important physiological role in energy metabolism; however, its expression and function in human pancreatic adenocarcinoma (PDAC) remain unknown. This study aimed to investigate the expression pattern and mechanisms of ac...

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Bibliographic Details
Main Authors: Ye Li, Jia Shen, Chien-shan Cheng, HuiFeng Gao, Jiangang Zhao, Lianyu Chen
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Cell & Bioscience
Subjects:
Pancreatic adenocarcinoma
Pyruvate dehydrogenase phosphatase 1
ATP
mTOR
AMPK
Online Access:http://link.springer.com/article/10.1186/s13578-020-00457-5

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