Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in Drosophila.

Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in Drosophila.

Prion diseases are rare and aggressive neurodegenerative disorders caused by the accumulation of misfolded, toxic conformations of the prion protein (PrP). Therapeutic strategies directed at reducing the levels of PrP offer the best chance of delaying or halting disease progression. The challenge, t...

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Bibliographic Details
Main Authors:	Yan Zhang, Sergio Casas-Tinto, Diego E Rincon-Limas, Pedro Fernandez-Funez
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3921213?pdf=render

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