Chaperones and Proteostasis: Role in Parkinson’s Disease
Proper folding to attain a defined three-dimensional structure is a prerequisite for the functionality of a protein. Improper folding that eventually leads to formation of protein aggregates is a hallmark of several neurodegenerative disorders. Loss of protein homeostasis triggered by cellular stres...
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doaj-24d55cade6e6494f89119951e79251852020-11-25T03:06:35ZengMDPI AGDiseases2079-97212020-06-018242410.3390/diseases8020024Chaperones and Proteostasis: Role in Parkinson’s DiseaseNeha Joshi0Atchaya S R1Shirisha Nagotu2Organelle Biology and Cellular Ageing Lab, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati-781039, Assam, IndiaOrganelle Biology and Cellular Ageing Lab, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati-781039, Assam, IndiaOrganelle Biology and Cellular Ageing Lab, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati-781039, Assam, IndiaProper folding to attain a defined three-dimensional structure is a prerequisite for the functionality of a protein. Improper folding that eventually leads to formation of protein aggregates is a hallmark of several neurodegenerative disorders. Loss of protein homeostasis triggered by cellular stress conditions is a major contributing factor for the formation of these toxic aggregates. A conserved class of proteins called chaperones and co-chaperones is implicated in maintaining the cellular protein homeostasis. Expanding the body of evidence highlights the role of chaperones as central mediators in the formation, de-aggregation and degradation of the aggregates. Altered expression and function of chaperones is associated with many neurodegenerative diseases including Parkinson’s disease. Several studies indicate that chaperones are at the center of the cause and effect cycle of this disease. An overview of the various chaperones that are associated with homeostasis of Parkinson’s disease-related proteins and their role in pathogenicity will be discussed in this review.https://www.mdpi.com/2079-9721/8/2/24neurodegenerationchaperonesheat shock proteinParkinson’s Diseasesynuclein |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Neha Joshi Atchaya S R Shirisha Nagotu |
spellingShingle |
Neha Joshi Atchaya S R Shirisha Nagotu Chaperones and Proteostasis: Role in Parkinson’s Disease Diseases neurodegeneration chaperones heat shock protein Parkinson’s Disease synuclein |
author_facet |
Neha Joshi Atchaya S R Shirisha Nagotu |
author_sort |
Neha Joshi |
title |
Chaperones and Proteostasis: Role in Parkinson’s Disease |
title_short |
Chaperones and Proteostasis: Role in Parkinson’s Disease |
title_full |
Chaperones and Proteostasis: Role in Parkinson’s Disease |
title_fullStr |
Chaperones and Proteostasis: Role in Parkinson’s Disease |
title_full_unstemmed |
Chaperones and Proteostasis: Role in Parkinson’s Disease |
title_sort |
chaperones and proteostasis: role in parkinson’s disease |
publisher |
MDPI AG |
series |
Diseases |
issn |
2079-9721 |
publishDate |
2020-06-01 |
description |
Proper folding to attain a defined three-dimensional structure is a prerequisite for the functionality of a protein. Improper folding that eventually leads to formation of protein aggregates is a hallmark of several neurodegenerative disorders. Loss of protein homeostasis triggered by cellular stress conditions is a major contributing factor for the formation of these toxic aggregates. A conserved class of proteins called chaperones and co-chaperones is implicated in maintaining the cellular protein homeostasis. Expanding the body of evidence highlights the role of chaperones as central mediators in the formation, de-aggregation and degradation of the aggregates. Altered expression and function of chaperones is associated with many neurodegenerative diseases including Parkinson’s disease. Several studies indicate that chaperones are at the center of the cause and effect cycle of this disease. An overview of the various chaperones that are associated with homeostasis of Parkinson’s disease-related proteins and their role in pathogenicity will be discussed in this review. |
topic |
neurodegeneration chaperones heat shock protein Parkinson’s Disease synuclein |
url |
https://www.mdpi.com/2079-9721/8/2/24 |
work_keys_str_mv |
AT nehajoshi chaperonesandproteostasisroleinparkinsonsdisease AT atchayasr chaperonesandproteostasisroleinparkinsonsdisease AT shirishanagotu chaperonesandproteostasisroleinparkinsonsdisease |
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1724673512159838208 |