MorphoSONIC: A morphologically structured intramembrane cavitation model reveals fiber-specific neuromodulation by ultrasound
Summary: Low-Intensity Focused Ultrasound Stimulation (LIFUS) holds promise for the remote modulation of neural activity, but an incomplete mechanistic characterization hinders its clinical maturation. Here we developed a computational framework to model intramembrane cavitation (a candidate mechani...
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doaj-2506b1e46a014410a4a5cd6090aa17032021-09-25T05:10:41ZengElsevieriScience2589-00422021-09-01249103085MorphoSONIC: A morphologically structured intramembrane cavitation model reveals fiber-specific neuromodulation by ultrasoundThéo Lemaire0Elena Vicari1Esra Neufeld2Niels Kuster3Silvestro Micera4Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), 1202 Lausanne, Switzerland; Corresponding authorBertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), 1202 Lausanne, Switzerland; Biorobotics Institute, Scuola Superiore Sant’Anna (SSSA), 56127 Pisa, ItalyFoundation for Research on Information Technologies in Society (IT’IS), 8004 Zurich, SwitzerlandFoundation for Research on Information Technologies in Society (IT’IS), 8004 Zurich, Switzerland; Department of Information Technology and Electrical Engineering, Swiss Federal Institute of Technology (ETH) Zurich, 8092 Zurich, SwitzerlandBertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), 1202 Lausanne, Switzerland; Biorobotics Institute, Scuola Superiore Sant’Anna (SSSA), 56127 Pisa, ItalySummary: Low-Intensity Focused Ultrasound Stimulation (LIFUS) holds promise for the remote modulation of neural activity, but an incomplete mechanistic characterization hinders its clinical maturation. Here we developed a computational framework to model intramembrane cavitation (a candidate mechanism) in multi-compartment, morphologically structured neuron models, and used it to investigate ultrasound neuromodulation of peripheral nerves. We predict that by engaging membrane mechanoelectrical coupling, LIFUS exploits fiber-specific differences in membrane conductance and capacitance to selectively recruit myelinated and/or unmyelinated axons in distinct parametric subspaces, allowing to modulate their activity concurrently and independently over physiologically relevant spiking frequency ranges. These theoretical results consistently explain recent empirical findings and suggest that LIFUS can simultaneously, yet selectively, engage different neural pathways, opening up opportunities for peripheral neuromodulation currently not addressable by electrical stimulation. More generally, our framework is readily applicable to other neural targets to establish application-specific LIFUS protocols.http://www.sciencedirect.com/science/article/pii/S2589004221010531Ultrasound technologyNeuroscienceComputer modeling |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Théo Lemaire Elena Vicari Esra Neufeld Niels Kuster Silvestro Micera |
spellingShingle |
Théo Lemaire Elena Vicari Esra Neufeld Niels Kuster Silvestro Micera MorphoSONIC: A morphologically structured intramembrane cavitation model reveals fiber-specific neuromodulation by ultrasound iScience Ultrasound technology Neuroscience Computer modeling |
author_facet |
Théo Lemaire Elena Vicari Esra Neufeld Niels Kuster Silvestro Micera |
author_sort |
Théo Lemaire |
title |
MorphoSONIC: A morphologically structured intramembrane cavitation model reveals fiber-specific neuromodulation by ultrasound |
title_short |
MorphoSONIC: A morphologically structured intramembrane cavitation model reveals fiber-specific neuromodulation by ultrasound |
title_full |
MorphoSONIC: A morphologically structured intramembrane cavitation model reveals fiber-specific neuromodulation by ultrasound |
title_fullStr |
MorphoSONIC: A morphologically structured intramembrane cavitation model reveals fiber-specific neuromodulation by ultrasound |
title_full_unstemmed |
MorphoSONIC: A morphologically structured intramembrane cavitation model reveals fiber-specific neuromodulation by ultrasound |
title_sort |
morphosonic: a morphologically structured intramembrane cavitation model reveals fiber-specific neuromodulation by ultrasound |
publisher |
Elsevier |
series |
iScience |
issn |
2589-0042 |
publishDate |
2021-09-01 |
description |
Summary: Low-Intensity Focused Ultrasound Stimulation (LIFUS) holds promise for the remote modulation of neural activity, but an incomplete mechanistic characterization hinders its clinical maturation. Here we developed a computational framework to model intramembrane cavitation (a candidate mechanism) in multi-compartment, morphologically structured neuron models, and used it to investigate ultrasound neuromodulation of peripheral nerves. We predict that by engaging membrane mechanoelectrical coupling, LIFUS exploits fiber-specific differences in membrane conductance and capacitance to selectively recruit myelinated and/or unmyelinated axons in distinct parametric subspaces, allowing to modulate their activity concurrently and independently over physiologically relevant spiking frequency ranges. These theoretical results consistently explain recent empirical findings and suggest that LIFUS can simultaneously, yet selectively, engage different neural pathways, opening up opportunities for peripheral neuromodulation currently not addressable by electrical stimulation. More generally, our framework is readily applicable to other neural targets to establish application-specific LIFUS protocols. |
topic |
Ultrasound technology Neuroscience Computer modeling |
url |
http://www.sciencedirect.com/science/article/pii/S2589004221010531 |
work_keys_str_mv |
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