Glucose tolerance during pulmonary exacerbations in children with cystic fibrosis.
BACKGROUND: Patients with Cystic Fibrosis (CF) are relatively insulinopenic and are at risk of diabetes, especially during times of stress. There is a paucity of data in the literature describing glucose tolerance during CF pulmonary exacerbations. We hypothesised that glucose tolerance would be wor...
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doaj-250827a930514ba998a28b186a3c15cd2020-11-25T01:08:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0179e4484410.1371/journal.pone.0044844Glucose tolerance during pulmonary exacerbations in children with cystic fibrosis.John WidgerMark R OliverMichele O'ConnellFergus J CameronSarath RanganathanPhil J RobinsonBACKGROUND: Patients with Cystic Fibrosis (CF) are relatively insulinopenic and are at risk of diabetes, especially during times of stress. There is a paucity of data in the literature describing glucose tolerance during CF pulmonary exacerbations. We hypothesised that glucose tolerance would be worse during pulmonary exacerbations in children with CF than during clinical stability. METHODS: Patients with CF, 10 years or older, admitted with a pulmonary exacerbation underwent an OGTT within 48 hours of admission. A repeat OGTT was performed 4 to 6 weeks post discharge when the patients were well. RESULTS: Nine patients completed the study. Four patients were found to have normal glucose tolerance, 3 with impaired and 2 with CF related diabetes during the exacerbation. Mean change in 2-hour glucose was 1.1 mmol (SD = 0.77). At the follow up OGTT, 8 of 9 (89%) remained within their respective glucose tolerance status groupings. CONCLUSION: The findings of this study show that there is little difference in glucose tolerance during CF exacerbations compared to clinical stability in the majority of patients.http://europepmc.org/articles/PMC3441597?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
John Widger Mark R Oliver Michele O'Connell Fergus J Cameron Sarath Ranganathan Phil J Robinson |
spellingShingle |
John Widger Mark R Oliver Michele O'Connell Fergus J Cameron Sarath Ranganathan Phil J Robinson Glucose tolerance during pulmonary exacerbations in children with cystic fibrosis. PLoS ONE |
author_facet |
John Widger Mark R Oliver Michele O'Connell Fergus J Cameron Sarath Ranganathan Phil J Robinson |
author_sort |
John Widger |
title |
Glucose tolerance during pulmonary exacerbations in children with cystic fibrosis. |
title_short |
Glucose tolerance during pulmonary exacerbations in children with cystic fibrosis. |
title_full |
Glucose tolerance during pulmonary exacerbations in children with cystic fibrosis. |
title_fullStr |
Glucose tolerance during pulmonary exacerbations in children with cystic fibrosis. |
title_full_unstemmed |
Glucose tolerance during pulmonary exacerbations in children with cystic fibrosis. |
title_sort |
glucose tolerance during pulmonary exacerbations in children with cystic fibrosis. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
BACKGROUND: Patients with Cystic Fibrosis (CF) are relatively insulinopenic and are at risk of diabetes, especially during times of stress. There is a paucity of data in the literature describing glucose tolerance during CF pulmonary exacerbations. We hypothesised that glucose tolerance would be worse during pulmonary exacerbations in children with CF than during clinical stability. METHODS: Patients with CF, 10 years or older, admitted with a pulmonary exacerbation underwent an OGTT within 48 hours of admission. A repeat OGTT was performed 4 to 6 weeks post discharge when the patients were well. RESULTS: Nine patients completed the study. Four patients were found to have normal glucose tolerance, 3 with impaired and 2 with CF related diabetes during the exacerbation. Mean change in 2-hour glucose was 1.1 mmol (SD = 0.77). At the follow up OGTT, 8 of 9 (89%) remained within their respective glucose tolerance status groupings. CONCLUSION: The findings of this study show that there is little difference in glucose tolerance during CF exacerbations compared to clinical stability in the majority of patients. |
url |
http://europepmc.org/articles/PMC3441597?pdf=render |
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