KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification

KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification

The acetyltransferases KAT2A and KAT2B are essential regulators of transcription, cell cycle progression and DNA repair. Here the authors describe a KAT2A/2B-dependent acetylome, and show that acetylation of the protein kinase PLK4 contributes to the regulation of centrosome number.

Bibliographic Details
Main Authors: Marjorie Fournier, Meritxell Orpinell, Cédric Grauffel, Elisabeth Scheer, Jean-Marie Garnier, Tao Ye, Virginie Chavant, Mathilde Joint, Fumiko Esashi, Annick Dejaegere, Pierre Gönczy, László Tora
Format: Article
Language:English
Published: Nature Publishing Group 2016-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13227
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spelling doaj-250c67199f71459cb19a3733c6507eda2021-05-11T10:44:52ZengNature Publishing GroupNature Communications2041-17232016-10-017111610.1038/ncomms13227KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplificationMarjorie Fournier0Meritxell Orpinell1Cédric Grauffel2Elisabeth Scheer3Jean-Marie Garnier4Tao Ye5Virginie Chavant6Mathilde Joint7Fumiko Esashi8Annick Dejaegere9Pierre Gönczy10László Tora11Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL)Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)Sir William Dunn School of Pathology, University of OxfordInstitut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL)Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)The acetyltransferases KAT2A and KAT2B are essential regulators of transcription, cell cycle progression and DNA repair. Here the authors describe a KAT2A/2B-dependent acetylome, and show that acetylation of the protein kinase PLK4 contributes to the regulation of centrosome number.https://doi.org/10.1038/ncomms13227
collection DOAJ
language English
format Article
sources DOAJ
author Marjorie Fournier
Meritxell Orpinell
Cédric Grauffel
Elisabeth Scheer
Jean-Marie Garnier
Tao Ye
Virginie Chavant
Mathilde Joint
Fumiko Esashi
Annick Dejaegere
Pierre Gönczy
László Tora
spellingShingle Marjorie Fournier
Meritxell Orpinell
Cédric Grauffel
Elisabeth Scheer
Jean-Marie Garnier
Tao Ye
Virginie Chavant
Mathilde Joint
Fumiko Esashi
Annick Dejaegere
Pierre Gönczy
László Tora
KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification
Nature Communications
author_facet Marjorie Fournier
Meritxell Orpinell
Cédric Grauffel
Elisabeth Scheer
Jean-Marie Garnier
Tao Ye
Virginie Chavant
Mathilde Joint
Fumiko Esashi
Annick Dejaegere
Pierre Gönczy
László Tora
author_sort Marjorie Fournier
title KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification
title_short KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification
title_full KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification
title_fullStr KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification
title_full_unstemmed KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification
title_sort kat2a/kat2b-targeted acetylome reveals a role for plk4 acetylation in preventing centrosome amplification
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-10-01
description The acetyltransferases KAT2A and KAT2B are essential regulators of transcription, cell cycle progression and DNA repair. Here the authors describe a KAT2A/2B-dependent acetylome, and show that acetylation of the protein kinase PLK4 contributes to the regulation of centrosome number.
url https://doi.org/10.1038/ncomms13227
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