Prevention of HIV-1 TAT Protein-Induced Peripheral Neuropathy and Mitochondrial Disruption by the Antimuscarinic Pirenzepine

Prevention of HIV-1 TAT Protein-Induced Peripheral Neuropathy and Mitochondrial Disruption by the Antimuscarinic Pirenzepine

HIV-associated distal sensory polyneuropathy (HIV-DSP) affects about one third of people with HIV and is characterized by distal degeneration of axons. The pathogenesis of HIV-DSP is not known and there is currently no FDA-approved treatment. HIV trans-activator of transcription (TAT) is associated...

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Bibliographic Details
Main Authors: May Madi Han, Katie E. Frizzi, Ronald J. Ellis, Nigel A. Calcutt, Jerel Adam Fields
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Neurology
Subjects:
HIV
tat
neuropathy
mitochondrial dysfunction
sciatic nerve
pirenzepine
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.663373/full

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