| Summary: | Objective: To explore the effect of hydromorphone hydrochloride combined with ropivacaine
for PCEA after orthopedic surgery on the synthesis of pain mediators, inflammatory mediator
and oxygen free radicals. Methods: A total of 120 patients with fracture who underwent
operation in the hospital between July 2014 and December 2016 were collected and divided
into control group and observation group according to the random number table method,
60 cases in each group. Control group received morphine hydrochloride combined with
ropivacaine for analgesia, observation group received hydromorphone hydrochloride combined
with ropivacaine for analgesia, and the postoperative analgesia lasted for 48 h. The differences
in serum levels of pain mediators, inflammatory mediators and oxidative stress indexes were
compared between the two groups. Results: Immediately after operation, the differences in
serum levels of pain mediators, inflammatory mediators and oxidative stress indexes were
not statistically significant between the two groups. 48 h after operation, serum PGE2, SP,
β-EP, IL-6, MCP-1, HMGB-1 and MDA levels of both groups of patients were significantly
lower than those immediately after operation while Cu-Zn SOD and GSH-Px levels were
significantly higher than those immediately after operation, and serum PGE2, SP, β-EP, IL-6,
MCP-1, HMGB-1 and MDA levels of observation group were significantly lower than those
of control group while Cu-Zn SOD and GSH-Px levels were significantly higher than those
of control group. Conclusion: Hydromorphone hydrochloride combined with ropivacaine
for PCEA after orthopedic surgery is effective in alleviating pain and inhibiting systemic
inflammatory response.
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