A recurrence of Guillain-Barr and eacute; syndrome or a case of acute-onset chronic inflammatory demyelinating polyneuropathy in the course of chronic hepatitis B?

• Main Authors: Guner Celik Koyuncu, Gulhan Kanat Unler, Huseyin Savas Gokturk
• Format: Article
• Language: English
• Published: Cukurova University 2016-12-01
• Series: Çukurova Üniversitesi Tıp Fakültesi Dergisi
• Subjects: Hepatitis B;Polyneuropathy;Antiviral therapy
• Online Access: http://www.scopemed.org/fulltextpdf.php?mno=215406

Chronic inflammatory demyelinating polyneuropathy is a demyelinating polyneuropathy characterized by distal/proximal weakness, which shows gradual progression over a period of 8 weeks or longer. Guillan-Barre Syndrome is a condition characterized by acute monophasic paralysis typically following an infectious assault, and it usually peaks in severity over 3-4 weeks at most. Although rare, there are acute-onset chronic inflammatory demyelinating polyneuropathy cases that show progression over a period shorter than 4 weeks, as is the case in Guillan-Barre Syndrome .This report discusses a case of chronic inflammatory demyelinating polyneuropathy in a HBsAg-positive patient, which started as Guillan-Barre Syndrome but showed 3 recurrences within 6 months, each with rapidly progressing quadriplegia, respiratory arrest, and elevated liver enzymes and HBV DNA. [Cukurova Med J 2016; 41(4.000): 782-786]