A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications

A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications

In GWAS, waist-to-hip ratio (WHR) is often adjusted for body mass index (BMI) to account for their correlation (WHRadjBMI). Here, Winkler et al. classify 159 genetic variants for BMI, WHR, or WHRadjBMI based on their effect directions for BMI and WHR to differentiate subtypes of adiposity genetics.

Bibliographic Details
Main Authors: Thomas W Winkler, Felix Günther, Simon Höllerer, Martina Zimmermann, Ruth JF Loos, Zoltán Kutalik, Iris M Heid
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04124-9
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spelling doaj-2516e462a68a41d99eb56cc05ac33e132021-05-11T10:15:43ZengNature Publishing GroupNature Communications2041-17232018-05-019111310.1038/s41467-018-04124-9A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implicationsThomas W Winkler0Felix Günther1Simon Höllerer2Martina Zimmermann3Ruth JF Loos4Zoltán Kutalik5Iris M Heid6Department of Genetic Epidemiology, University of RegensburgDepartment of Genetic Epidemiology, University of RegensburgDepartment of Genetic Epidemiology, University of RegensburgDepartment of Genetic Epidemiology, University of RegensburgThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount SinaiInstitute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV)Department of Genetic Epidemiology, University of RegensburgIn GWAS, waist-to-hip ratio (WHR) is often adjusted for body mass index (BMI) to account for their correlation (WHRadjBMI). Here, Winkler et al. classify 159 genetic variants for BMI, WHR, or WHRadjBMI based on their effect directions for BMI and WHR to differentiate subtypes of adiposity genetics.https://doi.org/10.1038/s41467-018-04124-9
collection DOAJ
language English
format Article
sources DOAJ
author Thomas W Winkler
Felix Günther
Simon Höllerer
Martina Zimmermann
Ruth JF Loos
Zoltán Kutalik
Iris M Heid
spellingShingle Thomas W Winkler
Felix Günther
Simon Höllerer
Martina Zimmermann
Ruth JF Loos
Zoltán Kutalik
Iris M Heid
A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications
Nature Communications
author_facet Thomas W Winkler
Felix Günther
Simon Höllerer
Martina Zimmermann
Ruth JF Loos
Zoltán Kutalik
Iris M Heid
author_sort Thomas W Winkler
title A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications
title_short A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications
title_full A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications
title_fullStr A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications
title_full_unstemmed A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications
title_sort joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-05-01
description In GWAS, waist-to-hip ratio (WHR) is often adjusted for body mass index (BMI) to account for their correlation (WHRadjBMI). Here, Winkler et al. classify 159 genetic variants for BMI, WHR, or WHRadjBMI based on their effect directions for BMI and WHR to differentiate subtypes of adiposity genetics.
url https://doi.org/10.1038/s41467-018-04124-9
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