Patients with Acromegaly Presenting with Colon Cancer: A Case Series
Introduction. Frequent colonoscopy screenings are critical for early diagnosis of colon cancer in patients with acromegaly. Case Presentations. We performed a retrospective analysis of the incidental diagnoses of colon cancer from the ACCESS trial (ClinicalTrials.gov identifier: NCT01995734). Colon...
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doaj-25180b8288044c87be73ebbfa5593ff72020-11-24T22:36:30ZengHindawi LimitedCase Reports in Endocrinology2090-65012090-651X2016-01-01201610.1155/2016/51562955156295Patients with Acromegaly Presenting with Colon Cancer: A Case SeriesMurray B. Gordon0Samer Nakhle1William H. Ludlam2Allegheny Neuroendocrinology Center, Departments of Medicine and Neurosurgery, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USAPalm Research Center, 9280 West Sunset Road, Suite 306, Las Vegas, NV 89148, USANovartis Pharmaceuticals, 1 Health Plaza, East Hanover, NJ 07936, USAIntroduction. Frequent colonoscopy screenings are critical for early diagnosis of colon cancer in patients with acromegaly. Case Presentations. We performed a retrospective analysis of the incidental diagnoses of colon cancer from the ACCESS trial (ClinicalTrials.gov identifier: NCT01995734). Colon cancer was identified in 2 patients (4.5%). Case 1 patient was a 36-year-old male with acromegaly who underwent transsphenoidal surgery to remove the pituitary adenoma. After surgery, the patient underwent routine colonoscopy screening, which revealed a 40 mm tubular adenoma in the descending colon. A T1N1a carcinoma was surgically removed, and 1 of 22 lymph nodes was positive for metastatic disease, leading to a diagnosis of stage 3 colon cancer. Case 2 patient was a 50-year-old male with acromegaly who underwent transsphenoidal surgery to remove a 2 cm pituitary adenoma. The patient reported severe cramping and lower abdominal pain, and an invasive 8.1 cm3 grade 2 adenocarcinoma with signet rings was identified in the ascending colon and removed. Of the 37 lymph nodes, 34 were positive for the presence of tumor cells, and stage 3c colon cancer was confirmed. Conclusion. Current guidelines for colonoscopy screening at the time of diagnosis of acromegaly and at appropriate follow-up intervals should be followed.http://dx.doi.org/10.1155/2016/5156295 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Murray B. Gordon Samer Nakhle William H. Ludlam |
spellingShingle |
Murray B. Gordon Samer Nakhle William H. Ludlam Patients with Acromegaly Presenting with Colon Cancer: A Case Series Case Reports in Endocrinology |
author_facet |
Murray B. Gordon Samer Nakhle William H. Ludlam |
author_sort |
Murray B. Gordon |
title |
Patients with Acromegaly Presenting with Colon Cancer: A Case Series |
title_short |
Patients with Acromegaly Presenting with Colon Cancer: A Case Series |
title_full |
Patients with Acromegaly Presenting with Colon Cancer: A Case Series |
title_fullStr |
Patients with Acromegaly Presenting with Colon Cancer: A Case Series |
title_full_unstemmed |
Patients with Acromegaly Presenting with Colon Cancer: A Case Series |
title_sort |
patients with acromegaly presenting with colon cancer: a case series |
publisher |
Hindawi Limited |
series |
Case Reports in Endocrinology |
issn |
2090-6501 2090-651X |
publishDate |
2016-01-01 |
description |
Introduction. Frequent colonoscopy screenings are critical for early diagnosis of colon cancer in patients with acromegaly. Case Presentations. We performed a retrospective analysis of the incidental diagnoses of colon cancer from the ACCESS trial (ClinicalTrials.gov identifier: NCT01995734). Colon cancer was identified in 2 patients (4.5%). Case 1 patient was a 36-year-old male with acromegaly who underwent transsphenoidal surgery to remove the pituitary adenoma. After surgery, the patient underwent routine colonoscopy screening, which revealed a 40 mm tubular adenoma in the descending colon. A T1N1a carcinoma was surgically removed, and 1 of 22 lymph nodes was positive for metastatic disease, leading to a diagnosis of stage 3 colon cancer. Case 2 patient was a 50-year-old male with acromegaly who underwent transsphenoidal surgery to remove a 2 cm pituitary adenoma. The patient reported severe cramping and lower abdominal pain, and an invasive 8.1 cm3 grade 2 adenocarcinoma with signet rings was identified in the ascending colon and removed. Of the 37 lymph nodes, 34 were positive for the presence of tumor cells, and stage 3c colon cancer was confirmed. Conclusion. Current guidelines for colonoscopy screening at the time of diagnosis of acromegaly and at appropriate follow-up intervals should be followed. |
url |
http://dx.doi.org/10.1155/2016/5156295 |
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