Effects of hyperbaric oxygen preconditioning on the postoperative oxidative stress activation in patients with TKA and THA restrictive transfusion
Objective: To study the effects of hyperbaric oxygen preconditioning on the postoperative oxidative stress activation in patients with total knee arthroplasty (TKA) and total hip arthroplasty (THA) restrictive transfusion. Methods: Patients who underwent THA and TKA and received restrictive trans...
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doaj-252ef0b9d6a3491da48e068026e312662020-11-24T20:44:36ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372018-08-0124163437Effects of hyperbaric oxygen preconditioning on the postoperative oxidative stress activation in patients with TKA and THA restrictive transfusionLing Qi0Cheng-Wei Wang1Xiu-Ping Yuan2. Hyperbaric Oxygen Chamber Room, Emergency Department, the Sixth Affiliated Hospital of Xinjiang Medical University, Urumchi, Xinjiang, 830002, ChinaDepartment of Orthopaedics, the Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830002, ChinaHyperbaric Oxygen Chamber Room, Bazhou People's Hospital of Korla Xinjiang, Korla, Xinjiang, 841000, ChinaObjective: To study the effects of hyperbaric oxygen preconditioning on the postoperative oxidative stress activation in patients with total knee arthroplasty (TKA) and total hip arthroplasty (THA) restrictive transfusion. Methods: Patients who underwent THA and TKA and received restrictive transfusion in the Sixth Affiliated Hospital of Xinjiang Medical University and Bazhou People's Hospital of Korla between June 2014 and December 2017 were selected and divided into HBOPC group and control group according to the application of preoperative hyperbaric oxygen preconditioning or not. The contents of oxidative stress indexes in serum as well as the expression intensity of oxidative stress molecules and immune molecules in peripheral blood were determined before surgery and 24 h after surgery. Results: Compared with those of same group before surgery, serum COR, NE, AT-II, MDA and ROS contents as well as peripheral blood JNK, Akt, FoxO3a, Nrf2, ARE, Foxp3 and GATA-3 expression intensity of both groups significantly increased whereas peripheral blood CD3, CD4 and T-bet expression intensity significantly decreased, and serum COR, NE, AT-II, MDA and ROS contents as well as peripheral blood JNK, Akt, FoxO3a, Nrf2, ARE, Foxp3 and GATA-3 expression intensity of HBOPC group after surgery were lower than those of control group whereas peripheral blood CD3, CD4 and T-bet expression intensity were higher than those of control group. Conclusion: Hyperbaric oxygen preconditioning can improve the postoperative oxidative stress response activation and immune response disorder in patients with TKA and THA restrictive transfusion.http://www.hnykdxxb.com/PDF/201816/09.pdf ArthroplastyRestrictive transfusionHyperbaric oxygen preconditioningOxidative stressImmune response |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ling Qi Cheng-Wei Wang Xiu-Ping Yuan |
spellingShingle |
Ling Qi Cheng-Wei Wang Xiu-Ping Yuan Effects of hyperbaric oxygen preconditioning on the postoperative oxidative stress activation in patients with TKA and THA restrictive transfusion Journal of Hainan Medical University Arthroplasty Restrictive transfusion Hyperbaric oxygen preconditioning Oxidative stress Immune response |
author_facet |
Ling Qi Cheng-Wei Wang Xiu-Ping Yuan |
author_sort |
Ling Qi |
title |
Effects of hyperbaric oxygen preconditioning on the postoperative oxidative stress activation in patients with TKA and THA restrictive transfusion |
title_short |
Effects of hyperbaric oxygen preconditioning on the postoperative oxidative stress activation in patients with TKA and THA restrictive transfusion |
title_full |
Effects of hyperbaric oxygen preconditioning on the postoperative oxidative stress activation in patients with TKA and THA restrictive transfusion |
title_fullStr |
Effects of hyperbaric oxygen preconditioning on the postoperative oxidative stress activation in patients with TKA and THA restrictive transfusion |
title_full_unstemmed |
Effects of hyperbaric oxygen preconditioning on the postoperative oxidative stress activation in patients with TKA and THA restrictive transfusion |
title_sort |
effects of hyperbaric oxygen preconditioning on the postoperative oxidative stress activation in patients with tka and tha restrictive transfusion |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2018-08-01 |
description |
Objective: To study the effects of hyperbaric oxygen preconditioning on the postoperative
oxidative stress activation in patients with total knee arthroplasty (TKA) and total hip
arthroplasty (THA) restrictive transfusion. Methods: Patients who underwent THA and
TKA and received restrictive transfusion in the Sixth Affiliated Hospital of Xinjiang Medical
University and Bazhou People's Hospital of Korla between June 2014 and December 2017
were selected and divided into HBOPC group and control group according to the application
of preoperative hyperbaric oxygen preconditioning or not. The contents of oxidative stress
indexes in serum as well as the expression intensity of oxidative stress molecules and immune
molecules in peripheral blood were determined before surgery and 24 h after surgery. Results:
Compared with those of same group before surgery, serum COR, NE, AT-II, MDA and ROS
contents as well as peripheral blood JNK, Akt, FoxO3a, Nrf2, ARE, Foxp3 and GATA-3
expression intensity of both groups significantly increased whereas peripheral blood CD3, CD4
and T-bet expression intensity significantly decreased, and serum COR, NE, AT-II, MDA and
ROS contents as well as peripheral blood JNK, Akt, FoxO3a, Nrf2, ARE, Foxp3 and GATA-3
expression intensity of HBOPC group after surgery were lower than those of control group
whereas peripheral blood CD3, CD4 and T-bet expression intensity were higher than those of
control group. Conclusion: Hyperbaric oxygen preconditioning can improve the postoperative
oxidative stress response activation and immune response disorder in patients with TKA and
THA restrictive transfusion. |
topic |
Arthroplasty Restrictive transfusion Hyperbaric oxygen preconditioning Oxidative stress Immune response |
url |
http://www.hnykdxxb.com/PDF/201816/09.pdf |
work_keys_str_mv |
AT lingqi effectsofhyperbaricoxygenpreconditioningonthepostoperativeoxidativestressactivationinpatientswithtkaandtharestrictivetransfusion AT chengweiwang effectsofhyperbaricoxygenpreconditioningonthepostoperativeoxidativestressactivationinpatientswithtkaandtharestrictivetransfusion AT xiupingyuan effectsofhyperbaricoxygenpreconditioningonthepostoperativeoxidativestressactivationinpatientswithtkaandtharestrictivetransfusion |
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1716816906095165440 |