Impact of Clostridioides difficile infection on the outcome of patients receiving a hematopoietic stem cell transplantation
Objectives: Clostridioides difficile infections (CDI) are common in autologous (auto-HSCT) or allogenic hematopoietic stem cell transplant (allo-HSCT) recipients. However, the impact of CDI on patient outcomes is controversial. We conducted this study to examine the impact of CDI on patient outcomes...
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Elsevier
2020-10-01
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Series: | International Journal of Infectious Diseases |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971220306597 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sarah Weber Sebastian Scheich Aaron Magh Sebastian Wolf Julius C. Enßle Uta Brunnberg Claudia Reinheimer Thomas A. Wichelhaus Volkhard A.J. Kempf Johanna Kessel Maria J.G.T. Vehreschild Hubert Serve Gesine Bug Björn Steffen Michael Hogardt |
spellingShingle |
Sarah Weber Sebastian Scheich Aaron Magh Sebastian Wolf Julius C. Enßle Uta Brunnberg Claudia Reinheimer Thomas A. Wichelhaus Volkhard A.J. Kempf Johanna Kessel Maria J.G.T. Vehreschild Hubert Serve Gesine Bug Björn Steffen Michael Hogardt Impact of Clostridioides difficile infection on the outcome of patients receiving a hematopoietic stem cell transplantation International Journal of Infectious Diseases Clostridioides difficile diarrhea hematopoietic stem cell transplantation acute myeloid leukemia lymphoma |
author_facet |
Sarah Weber Sebastian Scheich Aaron Magh Sebastian Wolf Julius C. Enßle Uta Brunnberg Claudia Reinheimer Thomas A. Wichelhaus Volkhard A.J. Kempf Johanna Kessel Maria J.G.T. Vehreschild Hubert Serve Gesine Bug Björn Steffen Michael Hogardt |
author_sort |
Sarah Weber |
title |
Impact of Clostridioides difficile infection on the outcome of patients receiving a hematopoietic stem cell transplantation |
title_short |
Impact of Clostridioides difficile infection on the outcome of patients receiving a hematopoietic stem cell transplantation |
title_full |
Impact of Clostridioides difficile infection on the outcome of patients receiving a hematopoietic stem cell transplantation |
title_fullStr |
Impact of Clostridioides difficile infection on the outcome of patients receiving a hematopoietic stem cell transplantation |
title_full_unstemmed |
Impact of Clostridioides difficile infection on the outcome of patients receiving a hematopoietic stem cell transplantation |
title_sort |
impact of clostridioides difficile infection on the outcome of patients receiving a hematopoietic stem cell transplantation |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 |
publishDate |
2020-10-01 |
description |
Objectives: Clostridioides difficile infections (CDI) are common in autologous (auto-HSCT) or allogenic hematopoietic stem cell transplant (allo-HSCT) recipients. However, the impact of CDI on patient outcomes is controversial. We conducted this study to examine the impact of CDI on patient outcomes. Methods: We performed a retrospective single-center study, including 191 lymphoma patients receiving an auto-HSCT and 276 acute myeloid leukemia (AML) patients receiving an allo-HSCT. The primary endpoint was overall survival (OS). Secondary endpoints were causes of death and, for the allo-HSCT cohort, GvHD- and relapse-free survival (GRFS). Results: The prevalence of CDI was 17.6% in the AML allo-HSCT and 7.3% in the lymphoma auto-HSCT cohort. A higher prevalence of bloodstream infections, but no differences concerning OS or cause of death were found for patients with CDI in the auto-HSCT cohort. [AU] In the allo-HSCT cohort, OS and GRFS were similar between CDI and non-CDI patients. However, the leading cause of death was relapse among non-CDI patients, but it was infectious diseases in the CDI group with fewer deaths due to relapse. Conclusions: CDI was not associated with worse survival in patients receiving a hematopoietic stem cell transplantation, and there were even fewer relapse-related deaths in the AML allo-HSCT cohort. |
topic |
Clostridioides difficile diarrhea hematopoietic stem cell transplantation acute myeloid leukemia lymphoma |
url |
http://www.sciencedirect.com/science/article/pii/S1201971220306597 |
work_keys_str_mv |
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doaj-252fac670d66471eae510bfe1bfc1bc92020-11-25T03:50:44ZengElsevierInternational Journal of Infectious Diseases1201-97122020-10-0199428436Impact of Clostridioides difficile infection on the outcome of patients receiving a hematopoietic stem cell transplantationSarah Weber0Sebastian Scheich1Aaron Magh2Sebastian Wolf3Julius C. Enßle4Uta Brunnberg5Claudia Reinheimer6Thomas A. Wichelhaus7Volkhard A.J. Kempf8Johanna Kessel9Maria J.G.T. Vehreschild10Hubert Serve11Gesine Bug12Björn Steffen13Michael Hogardt14Department of Hematology and Oncology, University Hospital Frankfurt, Frankfurt am Main, Germany; University Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt am Main, Germany; Corresponding Authors at: Universitätsklinikum Frankfurt am Main, Medizinische Klinik II – Hämatologie und Onkologie, Theodor-Stern Kai 7, 60590, Frankfurt, DeutschlandDepartment of Hematology and Oncology, University Hospital Frankfurt, Frankfurt am Main, Germany; University Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt am Main, Germany; Corresponding Authors at: Universitätsklinikum Frankfurt am Main, Medizinische Klinik II – Hämatologie und Onkologie, Theodor-Stern Kai 7, 60590, Frankfurt, DeutschlandDepartment of Hematology and Oncology, University Hospital Frankfurt, Frankfurt am Main, GermanyDepartment of Hematology and Oncology, University Hospital Frankfurt, Frankfurt am Main, Germany; University Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt am Main, GermanyDepartment of Hematology and Oncology, University Hospital Frankfurt, Frankfurt am Main, Germany; University Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt am Main, GermanyDepartment of Hematology and Oncology, University Hospital Frankfurt, Frankfurt am Main, Germany; University Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt am Main, GermanyUniversity Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt am Main, Germany; Institute of Medical Microbiology and Infection Control, University Hospital Frankfurt, Frankfurt am Main, Germany; University Center of Competence for Infection Control, State of Hesse, GermanyUniversity Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt am Main, Germany; Institute of Medical Microbiology and Infection Control, University Hospital Frankfurt, Frankfurt am Main, Germany; University Center of Competence for Infection Control, State of Hesse, GermanyUniversity Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt am Main, Germany; Institute of Medical Microbiology and Infection Control, University Hospital Frankfurt, Frankfurt am Main, Germany; University Center of Competence for Infection Control, State of Hesse, GermanyUniversity Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt am Main, Germany; Department of Medicine, Infectious Diseases Unit, University Hospital Frankfurt, Frankfurt am Main, GermanyUniversity Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt am Main, Germany; Department of Medicine, Infectious Diseases Unit, University Hospital Frankfurt, Frankfurt am Main, Germany; German Center of Infectious Diseases, Partner site Bonn-CologneDepartment of Hematology and Oncology, University Hospital Frankfurt, Frankfurt am Main, Germany; University Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt am Main, GermanyDepartment of Hematology and Oncology, University Hospital Frankfurt, Frankfurt am Main, Germany; University Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt am Main, GermanyDepartment of Hematology and Oncology, University Hospital Frankfurt, Frankfurt am Main, Germany; University Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt am Main, GermanyUniversity Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt am Main, Germany; Institute of Medical Microbiology and Infection Control, University Hospital Frankfurt, Frankfurt am Main, Germany; University Center of Competence for Infection Control, State of Hesse, GermanyObjectives: Clostridioides difficile infections (CDI) are common in autologous (auto-HSCT) or allogenic hematopoietic stem cell transplant (allo-HSCT) recipients. However, the impact of CDI on patient outcomes is controversial. We conducted this study to examine the impact of CDI on patient outcomes. Methods: We performed a retrospective single-center study, including 191 lymphoma patients receiving an auto-HSCT and 276 acute myeloid leukemia (AML) patients receiving an allo-HSCT. The primary endpoint was overall survival (OS). Secondary endpoints were causes of death and, for the allo-HSCT cohort, GvHD- and relapse-free survival (GRFS). Results: The prevalence of CDI was 17.6% in the AML allo-HSCT and 7.3% in the lymphoma auto-HSCT cohort. A higher prevalence of bloodstream infections, but no differences concerning OS or cause of death were found for patients with CDI in the auto-HSCT cohort. [AU] In the allo-HSCT cohort, OS and GRFS were similar between CDI and non-CDI patients. However, the leading cause of death was relapse among non-CDI patients, but it was infectious diseases in the CDI group with fewer deaths due to relapse. Conclusions: CDI was not associated with worse survival in patients receiving a hematopoietic stem cell transplantation, and there were even fewer relapse-related deaths in the AML allo-HSCT cohort.http://www.sciencedirect.com/science/article/pii/S1201971220306597Clostridioides difficilediarrheahematopoietic stem cell transplantationacute myeloid leukemialymphoma |