Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in Parkinson’s Disease
The impact of the gut microbiome is being increasingly appreciated in health and in various chronic diseases, among them neurodegenerative disorders such as Parkinson’s disease (PD). In the pathogenesis of PD, the role of the gut has been previously established. In conjunction with a bette...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-02-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/9/2/376 |
id |
doaj-2546d4e201444e5e99002234b1714887 |
---|---|
record_format |
Article |
spelling |
doaj-2546d4e201444e5e99002234b17148872020-11-25T01:38:25ZengMDPI AGCells2073-44092020-02-019237610.3390/cells9020376cells9020376Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in Parkinson’s DiseaseTobias Hegelmaier0Marco Lebbing1Alexander Duscha2Laura Tomaske3Lars Tönges4Jacob Bak Holm5Henrik Bjørn Nielsen6Sören G. Gatermann7Horst Przuntek8Aiden Haghikia9Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital Bochum, Bochum, 44791, GermanyClinic of Neurology II, EVK Hattingen, Hattingen 45525, GermanyDepartment of Neurology, Ruhr-University Bochum, St. Josef-Hospital Bochum, Bochum, 44791, GermanyDepartment of Neurology, Ruhr-University Bochum, St. Josef-Hospital Bochum, Bochum, 44791, GermanyDepartment of Neurology, Ruhr-University Bochum, St. Josef-Hospital Bochum, Bochum, 44791, GermanyClinical Microbiomics A/S, Copenhagen 2200, DenmarkClinical Microbiomics A/S, Copenhagen 2200, DenmarkDepartment of Medical Microbiology, Ruhr-University Bochum, Bochum, 44801, GermanyClinic of Neurology II, EVK Hattingen, Hattingen 45525, GermanyDepartment of Neurology, Ruhr-University Bochum, St. Josef-Hospital Bochum, Bochum, 44791, GermanyThe impact of the gut microbiome is being increasingly appreciated in health and in various chronic diseases, among them neurodegenerative disorders such as Parkinson’s disease (PD). In the pathogenesis of PD, the role of the gut has been previously established. In conjunction with a better understanding of the intestinal microbiome, a link to the misfolding and spread of alpha-synuclein via inflammatory processes within the gut is discussed. In a case-control study, we assessed the gut microbiome of 54 PD patients and 32 healthy controls (HC). Additionally, we tested in this proof-of-concept study whether dietary intervention alone or additional physical colon cleaning may lead to changes of the gut microbiome in PD. 16 PD patients underwent a well-controlled balanced, ovo-lacto vegetarian diet intervention including short fatty acids for 14 days. 10 of those patients received additional treatment with daily fecal enema over 8 days. Stool samples were collected before and after 14 days of intervention. In comparison to HC, we could confirm previously reported PD associated microbiome changes. The UDPRS III significantly improved and the levodopa-equivalent daily dose decreased after vegetarian diet and fecal enema in a one-year follow-up. Additionally, we observed a significant association between the gut microbiome diversity and the UPDRS III and the abundance of <i>Ruminococcaceae</i>. Additionally, the abundance of <i>Clostridiaceae</i> was significantly reduced after enema. Dietary intervention and bowel cleansing may provide an additional non-pharmacologic therapeutic option for PD patients.https://www.mdpi.com/2073-4409/9/2/376vegetarian dietenemaparkinson’s diseasemicrobiomebutyric acid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tobias Hegelmaier Marco Lebbing Alexander Duscha Laura Tomaske Lars Tönges Jacob Bak Holm Henrik Bjørn Nielsen Sören G. Gatermann Horst Przuntek Aiden Haghikia |
spellingShingle |
Tobias Hegelmaier Marco Lebbing Alexander Duscha Laura Tomaske Lars Tönges Jacob Bak Holm Henrik Bjørn Nielsen Sören G. Gatermann Horst Przuntek Aiden Haghikia Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in Parkinson’s Disease Cells vegetarian diet enema parkinson’s disease microbiome butyric acid |
author_facet |
Tobias Hegelmaier Marco Lebbing Alexander Duscha Laura Tomaske Lars Tönges Jacob Bak Holm Henrik Bjørn Nielsen Sören G. Gatermann Horst Przuntek Aiden Haghikia |
author_sort |
Tobias Hegelmaier |
title |
Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in Parkinson’s Disease |
title_short |
Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in Parkinson’s Disease |
title_full |
Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in Parkinson’s Disease |
title_fullStr |
Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in Parkinson’s Disease |
title_full_unstemmed |
Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in Parkinson’s Disease |
title_sort |
interventional influence of the intestinal microbiome through dietary intervention and bowel cleansing might improve motor symptoms in parkinson’s disease |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2020-02-01 |
description |
The impact of the gut microbiome is being increasingly appreciated in health and in various chronic diseases, among them neurodegenerative disorders such as Parkinson’s disease (PD). In the pathogenesis of PD, the role of the gut has been previously established. In conjunction with a better understanding of the intestinal microbiome, a link to the misfolding and spread of alpha-synuclein via inflammatory processes within the gut is discussed. In a case-control study, we assessed the gut microbiome of 54 PD patients and 32 healthy controls (HC). Additionally, we tested in this proof-of-concept study whether dietary intervention alone or additional physical colon cleaning may lead to changes of the gut microbiome in PD. 16 PD patients underwent a well-controlled balanced, ovo-lacto vegetarian diet intervention including short fatty acids for 14 days. 10 of those patients received additional treatment with daily fecal enema over 8 days. Stool samples were collected before and after 14 days of intervention. In comparison to HC, we could confirm previously reported PD associated microbiome changes. The UDPRS III significantly improved and the levodopa-equivalent daily dose decreased after vegetarian diet and fecal enema in a one-year follow-up. Additionally, we observed a significant association between the gut microbiome diversity and the UPDRS III and the abundance of <i>Ruminococcaceae</i>. Additionally, the abundance of <i>Clostridiaceae</i> was significantly reduced after enema. Dietary intervention and bowel cleansing may provide an additional non-pharmacologic therapeutic option for PD patients. |
topic |
vegetarian diet enema parkinson’s disease microbiome butyric acid |
url |
https://www.mdpi.com/2073-4409/9/2/376 |
work_keys_str_mv |
AT tobiashegelmaier interventionalinfluenceoftheintestinalmicrobiomethroughdietaryinterventionandbowelcleansingmightimprovemotorsymptomsinparkinsonsdisease AT marcolebbing interventionalinfluenceoftheintestinalmicrobiomethroughdietaryinterventionandbowelcleansingmightimprovemotorsymptomsinparkinsonsdisease AT alexanderduscha interventionalinfluenceoftheintestinalmicrobiomethroughdietaryinterventionandbowelcleansingmightimprovemotorsymptomsinparkinsonsdisease AT lauratomaske interventionalinfluenceoftheintestinalmicrobiomethroughdietaryinterventionandbowelcleansingmightimprovemotorsymptomsinparkinsonsdisease AT larstonges interventionalinfluenceoftheintestinalmicrobiomethroughdietaryinterventionandbowelcleansingmightimprovemotorsymptomsinparkinsonsdisease AT jacobbakholm interventionalinfluenceoftheintestinalmicrobiomethroughdietaryinterventionandbowelcleansingmightimprovemotorsymptomsinparkinsonsdisease AT henrikbjørnnielsen interventionalinfluenceoftheintestinalmicrobiomethroughdietaryinterventionandbowelcleansingmightimprovemotorsymptomsinparkinsonsdisease AT sorenggatermann interventionalinfluenceoftheintestinalmicrobiomethroughdietaryinterventionandbowelcleansingmightimprovemotorsymptomsinparkinsonsdisease AT horstprzuntek interventionalinfluenceoftheintestinalmicrobiomethroughdietaryinterventionandbowelcleansingmightimprovemotorsymptomsinparkinsonsdisease AT aidenhaghikia interventionalinfluenceoftheintestinalmicrobiomethroughdietaryinterventionandbowelcleansingmightimprovemotorsymptomsinparkinsonsdisease |
_version_ |
1725053903388540928 |